AI Article Synopsis
- Austin was first identified as a unique polyisoprenoid mycotoxin in 1976, leading to the discovery of various new austin-type meroterpenoids (ATMTs) over the years.
- A review covers 104 novel ATMTs found in five genera of fungi from both terrestrial and marine environments from 1976 to early 2023, highlighting that two genera are responsible for the majority of these compounds.
- Approximately 26.9% of the identified ATMTs show significant biological activities, including insecticidal and antibacterial effects, and the review emphasizes the importance of understanding their chemical diversity and the fungi sources for further research.
Article Abstract
Austin was first isolated as a novel polyisoprenoid mycotoxin from in 1976. Subsequently, some new austin-type meroterpenoids (ATMTs) have been continually found. This review attempts to give a comprehensive summary of progress on the isolation, chemical structural features, biological activities, and fungal biodiversity of 104 novel ATMTs from 5 genera of terrestrial- and marine-derived fungi reported from October 1976 to January 2023. The genera of and are the two dominant producers, producing 63.5% and 30.8% of ATMTs, respectively. Moreover, about 26.9% of ATMTs display various pronounced bioactivities, including insecticidal, anti-inflammatory, cytotoxicity, antibacterial, and PTP1B inhibitory activities. The chemical diversity and potential activities of these novel fungal ATMTs are reviewed for a better understanding, and a relevant summary focusing on the source fungi and their taxonomy is provided to shed light on the future development and research of austin-type meroterpenoids.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10890278 | PMC |
| http://dx.doi.org/10.3390/jof10020162 | DOI Listing |
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