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Deep Immunophenotyping of Circulating T and B Cells in Relapsing Adult-Onset Still's Disease. | LitMetric

AI Article Synopsis

  • - Adult-onset Still's disease (AOSD) is an inflammatory disorder that mainly involves abnormal immune responses, but the role of T and B cells in the disease is still not well understood.
  • - A study with 7 AOSD patients and 15 healthy individuals used deep flow cytometry to analyze T- and B-cell subsets, revealing significant alterations in these immune cells in AOSD patients compared to controls.
  • - Notable findings include decreased Th2 cells, changes in CD8+ T cell types, and a dramatic drop in a specific B cell subset (CD5+CD27-), suggesting the need for further research to understand these immune changes in AOSD.

Article Abstract

Adult-onset Still's disease (AOSD) is a complex systemic inflammatory disorder, categorized as an 'IL-1 driven' inflammasomapathy. Despite this, the interaction between T and B cells remains poorly understood. We conducted a study, enrolling 7 patients with relapsing AOSD and 15 healthy control subjects, utilizing deep flow cytometry analysis to examine peripheral blood T- and B-cell subsets. T-cell and B-cell subsets were significantly altered in patients with AOSD. Within CD4+ T cells, Th2 cells were decreased. Additionally, Th17 cell and follicular Th cell subsets were altered within CD45RA-CD62L+ and CD45RA-CD62L- Th cells in patients with AOSD compared to healthy controls. We identified changes in CD8+ T cell maturation and 'polarization' in AOSD patients, with an elevated presence of the TEMRA CD8+ T cell subset. Furthermore, the percentage of Tc1 cells was decreased, while the frequency of CCR6-CXCR3- Tc2 cells was elevated. Finally, we determined that the frequency of CD5+CD27- B cells was dramatically decreased in patients with AOSD compared to healthy controls. Further investigations on a large group of patients with AOSD are required to evaluate these adaptive immunity cells in the disease pathogenesis.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10887416PMC
http://dx.doi.org/10.3390/cimb46020075DOI Listing

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