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The impact of Charcot-Leyden Crystal protein on mesothelioma chemotherapy: targeting eosinophils for enhanced chemosensitivity.
EBioMedicine
November 2024
Molecular and Cellular Epigenetics (GIGA) and Molecular Biology (TERRA), University of Liege, Liege & Gembloux, Belgium. Electronic address:
Background: In mesothelioma (MPM), clinical evidence indicates that the absolute eosinophil count negatively correlates with overall survival and response to standard chemotherapy. Since eosinophils poorly infiltrate MPM tumours, we hypothesised that endocrine rather than paracrine pathways mediate the therapeutic response. We thus studied the effect of eosinophil-associated factors on response to chemotherapy in mesothelioma.
View Article and Find Full Text PDFEosinophil-Associated Genes are Potential Biomarkers for Hepatocellular Carcinoma Prognosis.
J Cancer
September 2024
The National & Local Joint Engineering Laboratory of Animal Peptide Drug Development, College of Life Science, Hunan Normal University, Changsha, 410081, China.
Article Synopsis
- Eosinophils are special white blood cells that help with allergies and fighting infections, but their role in liver cancer is not very clear.
- Scientists studied various genes related to eosinophils and created a risk model to see how they affect liver cancer survival.
- The research found that eosinophils are involved in liver cancer patients' survival, and certain genes associated with them can help predict how well a patient will do.
Notch 2 signaling contributes to intestinal eosinophil adaptations in steady state and tissue burden following oral allergen challenge.
J Leukoc Biol
July 2024
Division of Allergy and Inflammation, Department of Medicine, Beth Israel Deaconess Medical Center, 330 Brookline Ave, Boston, MA 02215, United States.
Eosinophils not only function as inflammatory effectors in allergic diseases, but also contribute to tissue homeostasis in steady state. Emerging data are revealing tissue eosinophils to be adaptive cells, imprinted by their local tissue microenvironment and exhibiting distinct functional phenotypes that may contribute to their homeostatic vs. inflammatory capacities.
View Article and Find Full Text PDFMucosal-associated invariant T cells modulate innate immune cells and inhibit colon cancer growth.
Scand J Immunol
September 2024
Division of Microbiology & Immunology, Department of Pathology, University of Utah, Salt Lake City, Utah, USA.
Mucosal-associated invariant T (MAIT) cells are innate-like T cells that can be activated by microbial antigens and cytokines and are abundant in mucosal tissues including the colon. MAIT cells have cytotoxic and pro-inflammatory functions and have potentials for use as adoptive cell therapy. However, studies into their anti-cancer activity, including their role in colon cancer, are limited.
View Article and Find Full Text PDFMouse eosinophil-associated ribonuclease-2 exacerbates the allergic response.
Allergy
August 2024
Department of Otolaryngology, Head and Neck Surgery, Kansai Medical University, Osaka, Japan.
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