AI Article Synopsis
- Strains of bacteria can be categorized into two groups based on the presence of a pathogenicity island (PAI), which influences their impact on human health.
- Colonization of the stomach by PAI-positive strains is linked to a higher risk of gastric cancer and peptic ulcers compared to PAI-negative strains.
- The PAI encodes a protein called CagA and a secretion system that helps deliver CagA into host cells, which triggers inflammation and contributes to gastric diseases.
Article Abstract
strains can be broadly classified into two groups based on whether they contain or lack a chromosomal region known as the pathogenicity island ( PAI). Colonization of the human stomach with PAI-positive strains is associated with an increased risk of gastric cancer and peptic ulcer disease, compared to colonization with PAI-negative strains. The PAI encodes a secreted effector protein (CagA) and components of a type IV secretion system (Cag T4SS) that delivers CagA and non-protein substrates into host cells. Animal model experiments indicate that CagA and the Cag T4SS stimulate a gastric mucosal inflammatory response and contribute to the development of gastric cancer. In this review, we discuss recent studies defining structural and functional features of CagA and the Cag T4SS and mechanisms by which strains containing the PAI promote the development of gastric cancer and peptic ulcer disease.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10896142 | PMC |
| http://dx.doi.org/10.1080/19490976.2024.2314201 | DOI Listing |
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