The International Narcotics Research Conference (INRC), founded in 1969, has been a successful forum for research into the actions of opiates, with an annual conference since 1971. Every year, scientists from around the world have congregated to present the latest data on novel opiates, opiate receptors and endogenous ligands, mechanisms of analgesic activity and unwanted side effects, etc. All the important discoveries in the opiate field were discussed, often first, at the annual INRC meeting. With an apology to important events and participants not discussed, this review presents a short history of INRC with a discussion of groundbreaking discoveries in the opiate field and the researchers who presented from the first meeting up to the present.
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http://dx.doi.org/10.3389/adar.2022.10115 | DOI Listing |
Talanta
January 2025
Department of Chemistry Education, Farhangian University, P.O. Box 14665-889, Tehran, Iran. Electronic address:
Although the dosage controlling of tramadol (TRA) as a banned deadly drug in human biofluids is medicolegally important a biocompatible method for its high-selective detection with fewer false interferences has been scarcely reported. Herein, a new impedimetric aptasensor is introduced by utilizing the aptamer (Apt) sequence with high affinity to TRA for the first time to non-invasively measure it. An oriented nanolayer of Au nanoparticles (AuNPs) is easily formed on the surface by the electrodeposition technique to high-densely load the Apt and embed the novel aptasensing interface via a user-friendly methodology.
View Article and Find Full Text PDFBMJ Open
January 2025
Division of Anesthesia Critical care, Emergency and Pain Medicine, University Hospital Centre Nimes, Nimes, Occitanie, France.
Introduction: Intensive care unit (ICU) patients under mechanical ventilation experience mild-to-severe pain. International guidelines emphasise the importance and benefits of multimodal analgesia to minimise opioid consumption and its side effects. However, no recommendation about drugs or protocol has been formulated.
View Article and Find Full Text PDFPain Pract
February 2025
Department of Anesthesiology, University California San Diego, San Diego, California, USA.
Background: Nonthermal, pulsed shortwave (radiofrequency) therapy (PSWT) is a nonpharmacologic, noninvasive modality that limited evidence suggests provides analgesia. Its potential favorable risk-benefit ratio stems from its lack of side effects and significant medical risks, applicability to any anatomic location, long treatment duration, and ease of application by simply affixing it with tape. Even with a relatively small treatment effect, PSWT might contribute to a multimodal analgesic regimen, similar to acetaminophen.
View Article and Find Full Text PDFBMJ Open
December 2024
The University of Sydney, Faculty of Medicine and Health, School of Health Sciences, Sydney, New South Wales, Australia.
Introduction: People experiencing low back pain (LBP) could potentially benefit from multimedia educational resources that integrate self-management strategies and improve awareness of the benefits of staying active and about medications that offer limited benefits, such as paracetamol. Primary care waiting rooms are potential spaces for presenting health promotion resources to improve health literacy through the dissemination of easily accessible health information. This feasibility study aims to explore the feasibility of conducting a large-scale trial to investigate the benefits of multimedia educational resources delivered at outpatient physiotherapy waiting rooms of public hospitals to support patients to participate in physical activity and reduce paracetamol intake for LBP.
View Article and Find Full Text PDFSensors (Basel)
January 2025
Department of Environmental Toxicology, Texas Tech University, Lubbock, TX 79409, USA.
Human nails have recently become a sample of interest for toxicological purposes. Multiple studies have proven the ability to detect various analytes within the keratin matrix of the nail. The analyte of interest in this study is fentanyl, a highly dangerous and abused drug in recent decades.
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