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The humeral head is the second most common anatomical site of osteonecrosis after the femoral head. Studies have reported satisfactory clinical outcomes after shoulder arthroplasty to treat osteonecrosis of the humeral head (ONHH). However, there are concerns regarding implant longevity in relatively young patients.

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In recent years, immune checkpoint inhibitors (ICIs) has emerged as a fundamental component of the standard treatment regimen for patients with head and neck squamous cell carcinoma (HNSCC). However, accurately predicting the treatment effectiveness of ICIs for patients at the same TNM stage remains a challenge. In this study, we first combined multi-omics data (mRNA, lncRNA, miRNA, DNA methylation, and somatic mutations) and 10 clustering algorithms, successfully identifying two distinct cancer subtypes (CSs) (CS1 and CS2).

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Voice Handicap Index-Throat: Translation and Cross-Cultural Adaptation to the Arabic Language.

J Voice

December 2024

Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, Università degli Studi di Brescia, Brescia, Italy; Unit of Otorhinolaryngology, Head and Neck Surgery, Azienda Socio Sanitaria Territoriale Spedali Civili Di Brescia, Brescia, Italy.

Objectives: This study aims to validate and assess the reliability of the Arabic version of the Voice Handicap Index-Throat (VHI-T), as a self-reported questionnaire for patients with throat difficulties.

Study Design: A prospective, observational, cross-sectional, and descriptive study was performed in the ear, nose, and throat department of Kafr El-Sheikh University hospitals from October 2023 to July 2024.

Methods: The preliminary VHI-T was obtained through forward and backward translation.

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Specific postural alignment alterations due to long-face deformity in patients with maxillo-mandibular deformities.

J Stomatol Oral Maxillofac Surg

December 2024

Sorbonne Université, APHP. Sorbonne Université, Hopital Pitié-Salpêtrière, Service de chirurgie maxillo-faciale, Paris, France; Arts et Métiers Sciences et Technologies, Institut de Biomécanique Humaine Georges Charpak, Paris, France.

Background: A specific pathological postural adaptation is suspected in patients exhibiting maxillo-mandibular deformity (MMD); however, none study reported a correlation between facial dimensions and posture. In this study, we hypothesized that pathological postural adaptations are related to long-face deformity and subsequent oral breathing in patients with MMD METHODS: Thirty patients with MMD and 20 healthy subjects. Breathing mode, postural alignment and cephalometry were analyzed through a biplanar X-ray (EOS imaging®) of the skeleton in an upright position, followed by three-dimensional reconstruction.

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Modeling the fasting blood glucose response to basal insulin adjustment in type 2 diabetes: An explainable machine learning approach on real-world data.

Int J Med Inform

December 2024

Department of Health Science and Technology, Aalborg University, Aalborg, Denmark; Data Science, Novo Nordisk A/S, Søborg, Denmark. Electronic address:

Introduction: Optimal basal insulin titration for people with type 2 diabetes is vital to effectively reducing the risk of complications. However, a sizeable proportion of people (30-50 %) remain in suboptimal glycemic control six months post-initiation of basal insulin. This indicates a clear need for novel titration methods that account for individual patient variability in real-world settings.

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