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Evaluation of a creatinine clearance correction equation based on body fat mass in older Japanese patients with diabetes. | LitMetric

AI Article Synopsis

  • The study focuses on improving the estimation of creatinine clearance (CCr) in older adults with diabetes, emphasizing that body composition changes can affect accuracy.
  • Researchers enrolled 50 older Japanese diabetic patients to compare actual CCr measurements with those estimated by the Cockcroft-Gault equation, analyzing body composition factors.
  • Results showed that a body fat mass (BFM)-corrected version of the Cockcroft-Gault equation was more accurate, including when BFM was measured using a simple household device, suggesting its potential for everyday clinical use.

Article Abstract

Background: The estimation of creatinine clearance (CCr) in older adult patients with diabetes is subject to deviations from the results of actual measurements because of changes in body composition. In the present study, we aimed to create a correction for the equation used for the estimation of CCr in older adult Asian patients with diabetes using body composition parameters.

Methods: We enrolled 50 older Japanese patients with diabetes in whom the measured values of CCr were compared with values estimated using the Cockcroft-Gault equation. The relationships between the error in the estimated CCr and body composition parameters were investigated, and the Cockcroft-Gault equation was corrected using the appropriate parameters. To evaluate the generalizability of the corrected equation, the utility of the Cockcroft-Gault equation, which was corrected on the basis of body composition measured using a household body composition meter, was also investigated.

Results: Body fat mass (BFM) was closely correlated with the error in the estimated CCr. The BFM-corrected Cockcroft-Gault equation was more accurate than the original equation. Similarly, the error became smaller using BFM measured with a household body composition meter.

Conclusion: The BFM-corrected Cockcroft-Gault equation may provide an accurate method of estimating CCr that can be used in general practice.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10881716PMC
http://dx.doi.org/10.3389/fmed.2024.1228383DOI Listing

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