AI Article Synopsis
- Research indicates a link between gut microbiota and spondyloarthritis (SpA), but the causal relationship is still uncertain.
- A comprehensive Mendelian randomization analysis revealed 23 potential causal connections, with Actinobacteria increasing ankylosing spondylitis risk and Rikenellaceae reducing risks for AS and psoriatic arthritis.
- The findings suggest that specific gut microbiota may play a genetic role in the development of SpA, offering insights into its mechanisms.
Article Abstract
Background: Despite establishing an association between gut microbiota and spondyloarthritis (SpA) subtypes, the causal relationship between them remains unclear.
Methods: Gut microbiota data were obtained from the MiBioGen collaboration, and SpA genome-wide association study (GWAS) summary data were obtained from the FinnGen collaboration. We conducted a two-sample Mendelian randomization (MR) analysis using the inverse-variance-weighted method supplemented with four additional MR methods (MR-Egger, weighted median, simple mode, and weighted mode). Pleiotropy and heterogeneity were also assessed. Reverse MR analysis was used to detect reverse causal relationships.
Results: We identified 23 causal links between specific gut microbiota taxa and SpA levels. Of these, 22 displayed nominal causal associations, and only one demonstrated a robust causal connection. Actinobacteria id.419 increased the risk of ankylosing spondylitis (AS) (odds ratio (OR) = 1.86 (95% confidence interval (CI): 1.29-2.69); = 8.63-04). The family Rikenellaceae id.967 was associated with a reduced risk of both AS (OR = 0.66 (95% CI: 0.47-0.93); = 1.81-02) and psoriatic arthritis (OR = 0.70 (95% CI: 0.50-0.97); = 3.00-02). Bacillales id.1674 increased the risk of AS (OR = 1.23 (95% CI: 1.00-1.51); = 4.94-02) and decreased the risk of enteropathic arthritis (OR = 0.56 (95% CI: 0.35-0.88); = 1.14-02). Directional pleiotropy, or heterogeneity, was not observed. No reverse causal associations were observed between the diseases and the gut microbiota.
Conclusion: Our MR analysis suggested a genetic-level causal relationship between specific gut microbiota and SpA, providing insights into the underlying mechanisms behind SpA development mediated by gut microbiota.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10883304 | PMC |
| http://dx.doi.org/10.3389/fimmu.2024.1284466 | DOI Listing |
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