AI Article Synopsis
- The study investigates the connection between frailty and liver fibrosis in middle-aged and older adults with non-alcoholic fatty liver disease (NAFLD), utilizing data from the National Health and Nutrition Examination Survey (NHANES) from 2017 to 2020.
- A frailty index was assessed alongside hepatic steatosis and fibrosis levels, revealing a significant relationship where higher frailty scores correlated with greater liver fibrosis even after adjusting for confounding factors.
- The results showed that the correlation was particularly strong among males, those with normal or overweight BMI, and individuals without hyperlipidemia, emphasizing the frailty index's potential role as a predictor of liver health in NAFLD patients.
Article Abstract
Background: Although previous studies found that frailty is prevalent in NAFLD patients with advanced liver fibrosis and cirrhosis, studies examining the relationship are spare.
Aim: Our study aspires to investigate the potential correlation between the Frailty Index (FI) and hepatic fibrosis among middle-aged and older adults with NAFLD.
Methods: Data from the 2017-2020.03 National Health and Nutrition Examination Survey (NHANES) were utilized for this study, with a final of 2,383 participants aged 50 years and older included. The quantification of frailty was executed employing a 49-item frailty index. The recognition of hepatic steatosis and fibrosis was accomplished through the utilization of the controlling attenuation parameter (CAP) and transient elastography (TE). The relationship between the FI and hepatic fibrosis were investigated employing univariable and multivariable-adjusted logistic regression analyses. A subgroup analysis was conducted, dividing the subjects based on gender, Body Mass Index (BMI), and the presence of hyperlipidemia.
Results: The findings demonstrated a positive correlation between the FI and significant hepatic fibrosis in NAFLD, even after using multivariate logistic regression models adjusting for potential confounding factors (OR = 1.022, 95% CI, 1.004-1.041) and in tertiles (Q3vs Q1: OR = 2.004, 95% CI, 1.162-3.455). In the subgroup analysis, the correlation was more statistically significant in male (OR = 1.046, 95% CI, 1.022-1.071), under/normal weight (OR = 1.077, 95% CI, 1.009-1.150), overweight (OR = 1.040, 95% CI, 1.010-1.071), and subjects without hyperlipidemia (OR = 1.054, 95% CI, 1.012-1.097). The area under the Receiver Operating Characteristic (ROC) curve for the FI in assessing the existence of substantial fibrosis in NAFLD was 0.612 (95% CI, 0.596-0.628).
Conclusion: This study demonstrated a positive correlation between significant hepatic fibrosis and frailty, particularly among males aged 50 years and older, who were non-obese and did not have hyperlipidemia with NAFLD. Additional studies are required to further validate these findings.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10883311 | PMC |
| http://dx.doi.org/10.3389/fpubh.2024.1330221 | DOI Listing |
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