Message: file_get_contents(https://...@gmail.com&api_key=61f08fa0b96a73de8c900d749fcb997acc09): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
Germline CDH1 mutations significantly increase the risk of developing diffuse gastric and lobular breast cancers, with risk estimates of up to 70% for men and 56% for women by age 80.
Prophylactic total gastrectomy is proposed as a potential life-saving option for carriers, since traditional endoscopic methods often miss early-stage gastric cancer.
The review explores the debate surrounding aggressive surgical interventions, weighing the benefits against possible contraindications and risks in certain clinical situations.
Article Abstract
Pathogenic germline CDH1 mutation confers high risk for developing diffuse gastric and lobular breast cancers in asymptomatic carriers. In these individuals, the estimated gastric cancer risk at 80 years of age is up to 70% for males and 56% for females. Due to this high-risk predisposition, prophylactic total gastrectomy is considered a unique life-saving approach in germline CDH1 carriers, as endoscopy often fails to detect early stage diffuse gastric carcinoma. However, surgical indication is controversial in some clinical contexts, with possible contraindications. This review discusses points against and in favor of a more aggressive surgical approach for consideration during the decision-making process.
