Synthetic data promises to be a viable alternative when data collection and data sharing may not be feasible or cost effective, but it raises distinct ethical issue that merit serious consideration. [Image: see text]
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http://dx.doi.org/10.1038/s44319-024-00101-0 | DOI Listing |
Ther Adv Musculoskelet Dis
March 2025
Division of Allergy, Immunology and Rheumatology, Department of Internal Medicine, Taichung Veterans General Hospital, No. 1650, Sec. 4, Taiwan Boulevard, Taichung 40705, Taiwan.
Background: Rheumatoid arthritis (RA) is complicated by a high risk of cardiovascular disease and requires the initiation of biological or targeted synthetic disease-modifying antirheumatic drugs (b/tsDMARDs) for persistently active disease despite first-line therapies. The influence of b/tsDMARDs, especially tsDMARDs, on cardiovascular risk in Taiwanese patients with RA remains unclear.
Objectives: To compare the risk of major cardiovascular adverse events (MACEs) or venous thromboembolism (VTE) amongst RA patients initiating approved b/tsDMARDs for up to 5 years.
Philos Trans A Math Phys Eng Sci
March 2025
Centre for Mathematical Medicine & Biology, School of Mathematical Sciences, University of Nottingham, Nottingham, UK.
The rapid delayed rectifier current carried by the human Ether-à-go-go-Related Gene (hERG) channel is susceptible to drug-induced reduction, which can lead to an increased risk of cardiac arrhythmia. Establishing the mechanism by which a specific drug compound binds to hERG can help reduce uncertainty when quantifying pro-arrhythmic risk. In this study, we introduce a methodology for optimizing experimental voltage protocols to produce data that enable different proposed models for the drug-binding mechanism to be distinguished.
View Article and Find Full Text PDFNutrients
March 2025
Department of Public Health and Infectious Diseases, Sapienza University of Rome, 00185 Rome, Italy.
: In recent decades, the need for sustainable alternatives to traditional foods for the global population has become urgent. To this aim, edible insects, cultivated meat, and vegetables produced through soil-less farming have been proposed. This cross-sectional study was aimed at exploring willingness to eat these novel foods and its possible correlates in young Italian adults.
View Article and Find Full Text PDFMaterials (Basel)
February 2025
Faculty of Humanities and Social Sciences, Macao Polytechnic University, Macao, China.
This study proposes a novel framework using graph convolutional networks to analyze and interpret X-ray diffraction patterns, addressing challenges in phase identification for multi-phase materials. By representing X-ray diffraction patterns as graphs, the framework captures both local and global relationships between diffraction peaks, enabling accurate phase identification even in the presence of overlapping peaks and noisy data. The framework outperforms traditional machine learning models, achieving a precision of 0.
View Article and Find Full Text PDFInt J Mol Sci
March 2025
Italian Foundation for Research on Bone Disease (F.I.R.M.O.), Via San Gallo 123, 50129 Firenze, Italy.
Estrogen receptor β (ERβ) is the most highly expressed subtype in the colon epithelium and mediates the protective effect of estrogen against the development of colon cancer. Indeed, the expression of this receptor is inversely related to colorectal cancer progression. Structurally estrogen-like compounds, including vitamin E components, affect cell growth by binding to ERs.
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