Objectives: In Japan, the most common injury requiring sick leave is a fall in the workplace; therefore, it is very important to prevent falls. Most measures to prevent falls involve aspects of the workplace environment and safety. However, few measures consider the perspective of individual health. We investigated the relationship between psychiatric disorders and falls in the workplace and whether treatment status for a psychiatric disorder is associated with workplace falls.
Methods: We conducted a cross-sectional study among workers aged 20 years or older in Japan from February 28 to March 3, 2022. In total, the data of 27 693 participants were analyzed. We used a questionnaire to query participants' status of treatment for any psychiatric disorder and whether they had experienced a fall in the workplace. The association between treatment for a psychiatric disorder and workplace falls was examined using logistic regression analysis.
Results: Compared with participants receiving appropriate treatment for a psychiatric disorder, the odds ratio (OR) of a workplace fall was significantly lower among participants who did not require treatment for a psychiatric disorder, at 0.56 (95% CI: 0.47-0.66; P < .001); the OR of a workplace fall was significantly higher among participants whose treatment for a psychiatric disorder was interrupted, at 1.47 (95% CI: 1.21-1.78; P < .001), after adjusting for age, sex, household income, number of workplace employees, sleeping hours, exercise habits, and psychological distress.
Conclusions: Our findings suggest that receiving appropriate treatment for psychiatric disorders may contribute to preventing falls in the workplace.
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http://dx.doi.org/10.1093/joccuh/uiae011 | DOI Listing |
JAMA Psychiatry
March 2025
Center for Neuropsychiatric Schizophrenia Research (CNSR& Center for Clinical Intervention and Neuropsychiatric Schizophrenia Research (CINS), Mental Health Centre Glostrup, Copenhagen University Hospital - Mental Health Services CPH, Copenhagen, Denmark.
Importance: Maternal inflammation during pregnancy has been associated with an increased risk of neurodevelopmental disorders (NDDs), such as attention-deficit/hyperactivity disorder (ADHD) and autism, and cognitive deficits in early childhood. However, little is known about the contributions of a wider range of inflammatory proteins to this risk.
Objective: To determine whether maternal inflammatory proteins during pregnancy are associated with the risk of NDDs and executive functions (EF) in middle childhood and to identify protein patterns associated with NDDs and EF.
JAMA Psychiatry
March 2025
Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, United Kingdom.
Importance: Expectancy effects are significant confounding factors in psychiatric randomized clinical trials (RCTs), potentially affecting the interpretation of study results. This narrative review is the first, to our knowledge, to explore the relationship between expectancy effects, compromised blinding integrity, and the effects of active treatment/placebo in psychiatric RCTs. Additionally, we present statistical and experimental approaches that may help mitigate the confounding impact of expectancy effects.
View Article and Find Full Text PDFJAMA Psychiatry
March 2025
Institute of Behavioral Science, Feinstein Institutes for Medical Research, Manhasset, New York.
Importance: Peripheral (blood-based) biomarkers for psychiatric illness could benefit diagnosis and treatment, but research to date has typically been low throughput, and traditional case-control studies are subject to potential confounds of treatment and other exposures. Large-scale 2-sample mendelian randomization (MR) can examine the potentially causal impact of circulating proteins on neuropsychiatric phenotypes without these confounds.
Objective: To identify circulating proteins associated with risk for schizophrenia (SCZ), bipolar disorder (BD), and major depressive disorder (MDD) as well as cognitive task performance (CTP).
Aging Dis
March 2025
First Clinical Medical College, Heilongjiang University of Chinese Medicine, Harbin 150040, China.
Recent advances in microbial pathogen research have highlighted the potential of gut microbe-based microbial medicine. One of the most extensively studied biological pathways is the gut-brain axis, which has been shown to reverse neurological disorders. Evidence from animal-based studies of dysbiosis suggest complex behavioral changes, such as alterations in sociability and anxiety, can be modulated through gut microbiota.
View Article and Find Full Text PDFAddict Biol
March 2025
Departament de Psicologia Bàsica, Clínica i Psicobiologia, Universitat Jaume I, Castellón, Spain.
Repetitive drug use results in enduring structural and functional changes in the brain. Addiction research has consistently revealed significant modifications in key brain networks related to reward, habit, salience, executive function, memory and self-regulation. Techniques like Voxel-based Morphometry have highlighted large-scale structural differences in grey matter across distinct groups.
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