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B Cell Markers of Operational Tolerance Can Discriminate Acute Kidney Allograft Rejection From Stable Graft Function.

Transplantation

May 2015

1 Department of Immunohaematology and Blood Transfusion, Leiden University Medical Center, Leiden, the Netherlands. 2 Department of Nephrology, Leiden University Medical Center, Leiden, the Netherlands. 3 Address correspondence to: Sebastiaan Heidt, M.D., Department of Immunohaematology and Blood Transfusion, Leiden University Medical Center, Albinusdreef 2-2333 ZA Leiden, the Netherlands.

Background: Recently, several B cell-related markers have been described to be upregulated during operational tolerance in kidney allograft recipients. Little data exist on these markers during allograft rejection.

Methods: In this study, we investigated regulation-associated B-cell phenotypes in peripheral blood mononuclear cells (PBMCs) of kidney transplant recipients with (n=21) and without (n=22) acute rejection (AR).

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