Rotary blood pumps in Extracorporeal Life Support (ECLS) applications are optimized for a specific design point. However, in clinical practice, these pumps are usually applied over a wide range of operation points. Studies have shown that a deviation from the design point in a rotary blood pump leads to an unexpected rise of hemolysis with corresponding clinical complications. Adjustable pumps that can adapt geometric parameters to the respective operation point are commonly used in other industrial branches, but yet not applied in blood pumps. We present a novel mechanism to adjust the impeller geometry of a centrifugal blood pump during operation together with in-vitro data of its hydraulic performance and efficiency. Three-dimensionalprinted prototypes of the adjustable impeller and a rigid impeller were manufactured and hydraulic performance and efficiency measured (n = 3). In a flow range of 1.5-9.5 L/min, the adjustable pump increased pump performance up to 47% and hydraulic efficiency by an average of 7.3 percentage points compared with a fixed setting. The adjustable pump allows customization of the pump's behavior (steepness of performance curve) according to individual needs. Furthermore, the hydraulic efficiency of the pump could be maintained at a high level throughout the complete flow range.
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http://dx.doi.org/10.1097/MAT.0000000000002163 | DOI Listing |
Poult Sci
January 2025
College of Animal Science and Technology, Jilin Agricultural University, Changchun 130118, China; Key Laboratory of Animal Production, Product Quality and Security, Ministry of Education, Changchun 130118, China; Jilin Key Laboratory of Animal Nutrition and Feed Science, Changchun 130118, China. Electronic address:
Hesperidin exhibits promising potential as a feed additive for augmenting gastric acid secretion in animals. Gastrointestinal function is essential for animal growth and the efficient digestion of dietary nutrients, with gastric acid secretion serving as one of its critical components. The secretion of gastric acid, together with other digestive fluids and substances, significantly influences the digestion and absorption of animal feed, which in turn affects growth performance.
View Article and Find Full Text PDFFront Immunol
January 2025
College of Pharmacy, University of Houston, Houston, TX, United States.
Background: Proton pump inhibitors (PPIs) are one of the most used drugs worldwide. While generally considered safe, the usage of PPIs is associated with several adverse outcomes including acute infectious diseases. PPIs influence macrophage and neutrophil function although a systematic review has never been undertaken.
View Article and Find Full Text PDFJ Artif Organs
January 2025
Department of Artificial Organs, National Cerebral and Cardiovascular Center, 6-1 Kishibe-Shinmachi, Suita, Osaka, 5648565, Japan.
This review traces the evolution of centrifugal blood pumps in mechanical circulatory support (MCS) systems. Initially met with concerns over blood damage and thrombus formation, centrifugal pumps have become crucial components in ventricular assist devices (VADs) and extracorporeal membrane oxygenation (ECMO) due to their simplified drive mechanisms and adaptability. This paper outlines three generations of centrifugal pump development: first-generation pumps with sealing components, second-generation pumps utilizing pivot bearings, and third-generation pumps employing contactless bearings.
View Article and Find Full Text PDFNat Med
January 2025
Parkinson's Disease Centre of Excellence, Department of Neurology, Univeristy of Lille, CHU Lille, INSERM U1172-Degenerative & Vascular Cognitive Disorders, Lille, France.
Continuous compensation for cerebral dopamine deficiency represents an ideal treatment for Parkinson's disease. Dopamine does not cross the digestive and blood-brain barriers and is rapidly oxidized. The new concept is the intracerebroventricular administration of anaerobic dopamine (A-dopamine) using an abdominal pump connected to a subcutaneous catheter implanted in the third ventricle, near the striatum.
View Article and Find Full Text PDFPhytomedicine
December 2024
Hebei Key Laboratory of Critical Disease Mechanism and Intervention, Department of Pathophysiology, Neuroscience Research Center, The Key Laboratory of Neural and Vascular Biology, Ministry of Education, Hebei Medical University, 361 Zhongshan East Road, Shijiazhuang 050017, China. Electronic address:
Background: In China, stroke is the primary cause of adult death and disability. Because of the increased rate of blood vessel reperfusion, it is important to prevent cerebral ischemia-reperfusion injury, in which glutamate (Glu) excitotoxicity plays a critical role. The most important Glu transporter, GLT-1, is essential for the regulation of Glu, which is dependent on Na-K-ATPase (NKA)-induced ion concentration gradient differences.
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