AI Article Synopsis
- A systematic review and meta-analysis was conducted to assess early clinical outcomes associated with the Impella 5.5 device, involving a search of literature from September 2019 to March 2023.
- The analysis included 15 studies with 707 patients, revealing a survival rate to hospital discharge of 68% and a 30-day survival rate of 65% for patients using Impella devices, mainly Impella 5.5.
- Among 294 patients treated specifically with Impella 5.5, the survival to discharge rate was notably higher at 78%, indicating promising early outcomes as experience with this device increases.
Article Abstract
Data regarding outcomes with Impella 5.5 are limited. The aim of this systematic review and meta-analysis was to summarize patient and treatment characteristics and early clinical outcomes among patients supported by Impella 5.5. A systematic literature search was conducted in PubMed, Scopus, and Cochrane databases from September 2019 to March 2023. Studies reporting outcomes in greater than or equal to 5 patients were included for review. Patient characteristics, treatment characteristics, and early clinical outcomes were extracted. Outcomes included adverse events, survival to hospital discharge, and 30 day survival. Random-effect models were used to estimate pooled effects for survival outcomes. Assessment for bias was performed using funnel plots and Egger's tests. Fifteen studies were included for qualitative review, representing 707 patients. Mean duration of support was 9.9 ± 8.2 days. On meta-analysis of 13 studies reporting survival outcomes, survival to hospital discharge was 68% (95% confidence interval [CI], 58-78%), and 30 day survival was 65% (95% CI, 56-74%) among patients with Impella devices predominantly supported by Impella 5.5 (>60%). There was significant study heterogeneity for these outcomes. Among 294 patients with Impella 5.5 only, survival to discharge was 78% (95% CI, 72-82%) with no significant study heterogeneity. This data present early benchmarks for outcomes with Impella 5.5 as clinical experience with these devices accrues.
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| http://dx.doi.org/10.1097/MAT.0000000000002169 | DOI Listing |
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