AI Article Synopsis
- * The study finds that specific receptors (SFRs), particularly CD48 on NK cells and its counterpart 2B4 on macrophages, are crucial for the expansion of these adaptive NK cells post-infection.
- * The interaction between 2B4 and CD48 helps prevent the phagocytosis (cell engulfing) of Ly49H NK cells by activating macrophages, suggesting that enhancing this pathway could improve NK cell responses in therapies.
Article Abstract
Infection of mice by mouse cytomegalovirus (MCMV) triggers activation and expansion of Ly49H natural killer (NK) cells, which are virus specific and considered to be "adaptive" or "memory" NK cells. Here, we find that signaling lymphocytic activation molecule family receptors (SFRs), a group of hematopoietic cell-restricted receptors, are essential for the expansion of Ly49H NK cells after MCMV infection. This activity is largely mediated by CD48, an SFR broadly expressed on NK cells and displaying augmented expression after MCMV infection. It is also dependent on the CD48 counter-receptor, 2B4, expressed on host macrophages. The 2B4-CD48 axis promotes expansion of Ly49H NK cells by repressing their phagocytosis by virus-activated macrophages through inhibition of the pro-phagocytic integrin lymphocyte function-associated antigen-1 (LFA-1) on macrophages. These data identify key roles of macrophages and the 2B4-CD48 pathway in controlling the expansion of adaptive NK cells following MCMV infection. Stimulation of the 2B4-CD48 axis may be helpful in enhancing adaptive NK cell responses for therapeutic purposes.
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| http://dx.doi.org/10.1016/j.celrep.2024.113800 | DOI Listing |
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Article Synopsis
- * The study finds that specific receptors (SFRs), particularly CD48 on NK cells and its counterpart 2B4 on macrophages, are crucial for the expansion of these adaptive NK cells post-infection.
- * The interaction between 2B4 and CD48 helps prevent the phagocytosis (cell engulfing) of Ly49H NK cells by activating macrophages, suggesting that enhancing this pathway could improve NK cell responses in therapies.
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