AI Article Synopsis
- The research focused on creating radiotracers that specifically target bacterial infections by utilizing the unique iron transport system known as siderophores.
- The synthesis and radiolabeling process produced a radiotracer called [Ga]Ga-RMA693, derived from salmochelin.
- In tests with an animal model of infection, this radiotracer demonstrated a favorable distribution in the body and targeted uptake in the presence of bacteria.
Article Abstract
For specific imaging of bacterial infections we aimed at targeting the exclusive bacterial iron transport system siderophore-based radiotracers. synthesis and radiolabeling yielded the salmochelin-based PET radiotracer [Ga]Ga-RMA693, which showed a favourable biodistribution and a bacteria-specific uptake in an animal model of infection.
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| http://dx.doi.org/10.1039/d4cc00255e | DOI Listing |
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