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Expression features of T-lymphocytes, B-lymphocytes and macrophages in the post-traumatic regenerate of the mandible rats under conditions of filling a bone defect with hydroxyapatite-containing osteotropic material and thymalin injecting the surrounding soft tissues.
Pol Merkur Lekarski
April 2024
Kharkiv National Medical University, Kharkiv, Ukraine.
Article Synopsis
- The study aimed to explore how T-lymphocytes, B-lymphocytes, and macrophages express in the mandible of rats after a simulated bone injury, particularly focusing on the effects of using hydroxyapatite-containing material and thymalin injections.
- Conducted on 48 mature rats divided into four groups, the experiment involved creating bone defects and employing different treatments including bone grafts and thymalin to assess their impact.
- Results showed that thymalin injections significantly enhanced the local immune response, increasing both T-lymphocyte and B-lymphocyte counts at various points throughout the 28-day observation period.
Objective: Aim of the study was to identify the morphological features of reparative osteogenesis in the lower jaw bone of rats in cases of filling a bone defect with hydroxyapatite-containing osteotropic material (bone graft "Biomin GT") and injecting the surrounding soft tissues with thymalin.
Patients And Methods: Materials and Methods: An experiment was conducted on 48 mature rats of the WAG population weighing 160-180 grams which were divided into four groups. Group 1 included 12 rats with a simulated holey defect in the lower jaw.
The Influence of KE and EW Dipeptides in the Composition of the Thymalin Drug on Gene Expression and Protein Synthesis Involved in the Pathogenesis of COVID-19.
Int J Mol Sci
August 2023
Saint Petersburg Institute of Bioregulation and Gerontology, 197110 Saint Petersburg, Russia.
Thymalin is an immunomodulatory drug containing a polypeptide extract of thymus that has demonstrated efficacy in the therapy of acute respiratory distress syndrome and chronic obstructive pulmonary disease, as well as in complex therapy related to severe COVID-19 in middle-aged and elderly patients.. KE and EW dipeptides are active substances of Thymalin.
View Article and Find Full Text PDF[Morphological compound and indicators of the blood clotting system in severe COVID-19 patients of middle aged and elderly during treatment of Tocilizumab and Thymalin.].
Adv Gerontol
September 2022
Belgorod State National Research University, 85 Pobedy str, Belgorod 308015, Russian Federation.
The aim of the work was a comparative study of Tocilizumab and Thymalin effects on the morphological composition and indicators of the blood clotting system in COVID-19 of middle aged and elderly patients. Severe COVID-19 patients were divided into 3 groups: 1st - control (basic therapy), 2nd - basic therapy +Tocilizumab, 3rd - basic therapy +Thymalin. Hospital mortality in COVID-19 patients after standard therapy, Tocilizumab and Thymalin application was 40,9; 28,4 and 20,6% accordingly.
View Article and Find Full Text PDFPeptides Regulating Proliferative Activity and Inflammatory Pathways in the Monocyte/Macrophage THP-1 Cell Line.
Int J Mol Sci
March 2022
Department of Innovative Technology in Medicine and Odontoiatrics, Center of Advanced Studies and Technology University "G. d'Annunzio", Chieti-Pescara, 66100 Chieti, Italy.
This study evaluates the effects of five different peptides, the Epitalon tetrapeptide, the Vilon dipeptide, the Thymogen dipeptide, the Thymalin peptide complex, and the Chonluten tripeptide, as regulators of inflammatory and proliferative processes in the human monocytic THP-1, which is a human leukemia monocytic cell line capable of differentiating into macrophages by PMA in vitro. These peptides (Khavinson Peptides), characterized by Prof. Khavinson from 1973 onwards, were initially isolated from animal tissues and found to be organ specific.
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