Background & Aims: Porto-sinusoidal vascular disorder (PSVD) encompasses a group of liver diseases with vascular abnormalities that can cause portal hypertension in the absence of cirrhosis. The new diagnostic criteria allow for coexistence with other liver diseases, however its relationship with chronic hepatitis B (CHB) remains unclear. This study aimed to assess HBV prevalence in a PSVD cohort and evaluate its clinical impact.
Methods: This retrospective study was conducted on patients with PSVD at Hospital Clínic Barcelona. HBV serology was evaluated, and patients were categorized into HBV chronic infection, past infection, or no HBV exposure. Clinical characteristics and outcomes were compared.
Results: We included 155 patients with PSVD. Prevalence of CHB and past HBV infection in patients with PSVD was higher than in the general population (5.8% . 0.5%, <0.0001 and 20% 9.1%, <0.0001, respectively). Patients with CHB had a significant delay in PSVD diagnosis compared to those without CHB (11 [5-25] . 1 [0-3] years, = 0.002) and had a more advanced disease (MELD score 12 [9-17] . 9 [7-11], = 0.012) at the time of PSVD diagnosis. The clinical evolution of PSVD in patients with CHB was marked by a significantly higher transplantation rate at the last follow-up (33% 4.1%, = 0.001).
Conclusions: Recognizing the coexistence of PSVD and CHB is important for timely diagnosis and optimal management, highlighting the potential benefits of specialized care for potentially improved outcomes.
Impact And Implications: The new diagnostic criteria for porto-sinusoidal vascular disorder (PSVD) allow for coexistence with other liver diseases. The results of the present study highlight, for the first time, a non-negligible prevalence of chronic hepatitis B in the PSVD population that was previously unknown. Coexistence may challenge and delay the PSVD diagnosis and is associated with a more unfavorable clinical course. Our findings will increase awareness of this coexistence and improve PSVD diagnosis and management. Furthermore, the data will encourage new studies to determine the prevalence and clinical behavior of other chronic liver diseases that coexist with PSVD.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10879788 | PMC |
| http://dx.doi.org/10.1016/j.jhepr.2023.100996 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Metabolomic profiles differentiate between porto-sinusoidal vascular disorder, cirrhosis, and healthy individuals.
JHEP Rep
December 2024
Division of Gastroenterology and Hepatology, Department of Medicine III, Medical University of Vienna, Vienna, Austria.
Article Synopsis
- The study focused on identifying unique metabolomic signatures in patients with porto-sinusoidal vascular disorder (PSVD) and cirrhosis to improve diagnosis.
- Serum samples from healthy volunteers and patients with PSVD or cirrhosis were analyzed using advanced techniques like liquid chromatography-mass spectrometry, identifying significant metabolic changes linked to PSVD.
- Machine learning models were developed to distinguish PSVD from cirrhosis and healthy controls; key metabolites like taurocholic acid showed strong potential for non-invasive diagnostic use.
Poor long-term outcome in patients with porto-sinusoidal vascular disease (PSVD): fact or disease misclassification?
J Hepatol
November 2024
Barcelona Hepatic Hemodynamic Laboratory, Liver Unit, Hospital Clínic, Institut de Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS). CIBEREHD (Centro de Investigación Biomédica en Red Enfermedades Hepáticas y Digestivas). Health Care Provider of the European Reference Network on Rare Liver Disorders (ERN RARE-Liver). Departament de Medicina i Ciències de la Salut. Universitat de Barcelona. Electronic address:
Porto-sinusoidal vascular disorder with known etiologies had more severe portal hypertension and poorer outcomes.
Dig Liver Dis
November 2024
Liver Research Center, Beijing Friendship Hospital, Capital Medical University, Beijing, China; State Key Laboratory of Digestive Health and National Clinical Research Center of Digestive Disease, Beijing, China. Electronic address:
Background: Porto-sinusoidal vascular disorder (PSVD) is a clinicopathological entity and often associated with various etiologies. We aimed to compare the clinical and pathological features and outcomes of PSVD in patients with and without known etiologies in a Chinese cohort.
Methods: This retrospective study enrolled liver-biopsy confirmed patients with PSVD.
Microcirculatory Perfusion Disturbances During Veno-Arterial Extracorporeal Membrane Oxygenation: A Systematic Review.
Microcirculation
November 2024
Department of Intensive Care Medicine, Amsterdam UMC Location University of Amsterdam, Amsterdam, The Netherlands.
Article Synopsis
- VA-ECMO (veno-arterial extracorporeal membrane oxygenation) is used to treat severe cardiac failure and can restore overall blood circulation, but its impact on small blood vessel function is still unclear.
- A systematic review of the literature (1215 studies sourced, 11 included) focused on how VA-ECMO affects microcirculation, measuring factors like small vessel density and blood flow.
- Initial findings suggest that microcirculatory function improves within hours for survivors of cardiac events post-ECMO, but this improvement levels off; more extensive research is needed to confirm these effects over time.
Porto-Sinusoidal Vascular Disease: A New Nomenclature Different from Idiopathic Non-Cirrhotic Portal Hypertension.
Diagnostics (Basel)
September 2024
Department of Hepatology, Tianjin Second People's Hospital, Tianjin 300192, China.
Background And Aims: Porto-sinusoidal vascular disease (PSVD) as a novel clinical conception was modified on the basis of idiopathic non-cirrhotic portal hypertension (INCPH). This study aimed to compare the clinical, biochemical histological features and prognosis between the diagnostic criteria for PSVD and that of INCPH.
Methods: A total of 65 patients who underwent liver biopsies were analyzed retrospectively.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!