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Numerical simulation of coal particle motion characteristics in the envelope region of spiral drum based on discrete element method.
Sci Rep
January 2025
College of Mechanical and Electrical Engineering, Zhoukou Normal University, Zhoukou, 466000, China.
In order to study the movement characteristics of coal particles in the coal loading process of spiral drums, the spiral drum of a certain type of shearer was taken as the research object, and the intrinsic parameters of the materials were calibrated through the determination results of coal sample properties, the relevant parameters of coal particle adhesion were determined, and a discrete element model of spiral drum coal loading was established. The distribution of coal particle movement subsequent to the fracture of the coal wall was derived through simulation. By spatially dividing the envelope region of the spiral drum along the radial and axial directions, the number and velocity distribution of coal particles in different envelope regions were obtained.
View Article and Find Full Text PDFImproved Analysis for Intrinsic Properties of Triaxial Accelerometers to Reduce Calibration Uncertainty.
Micromachines (Basel)
December 2024
NIST, Gaithersburg, MD 20899, USA.
We describe a modification of a previously described measurement-analysis protocol to determine the intrinsic properties of triaxial accelerometers by using a measurement protocol based on angular stepwise rotation in the Earth's gravitational field. This study was conducted with MEMS triaxial accelerometers that were co-integrated in four consumer-grade wireless microsensors. The measurements were carried out on low-cost rotation tables in different laboratories in different countries to simulate the reproducibility environment encountered in inter-comparisons of calibration capabilities.
View Article and Find Full Text PDFAn Ultra-Fast Validated Green UPLC-MS/MS Approach for Assessing Revumenib in Human Liver Microsomes: In Vitro Absorption, Distribution, Metabolism, and Excretion and Metabolic Stability Evaluation.
Medicina (Kaunas)
November 2024
Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia.
Revumenib (SNDX-5613) is a powerful and specific inhibitor of the menin-KMT2A binding interaction. It is a small molecule that is currently being researched to treat KMT2A-rearranged (KMT2Ar) acute leukemias. Revumenib (RVB) has received Orphan Drug Designation from the US FDA for treating patients with AML.
View Article and Find Full Text PDFPassive and active suppression of transduced noise in silicon spin qubits.
Nat Commun
January 2025
Department of Physics and Astronomy, and Institute of Applied Physics, Seoul National University, Seoul, Korea.
Addressing and mitigating decoherence sources plays an essential role in the development of a scalable quantum computing system, which requires low gate errors to be consistently maintained throughout the circuit execution. While nuclear spin-free materials, such as isotopically purified silicon, exhibit intrinsically promising coherence properties for electron spin qubits, the omnipresent charge noise, when converted to magnetic noise under a strong magnetic field gradient, often hinders stable qubit operation within a time frame comparable to the data acquisition time. Here, we demonstrate both open- and closed-loop suppression techniques for the transduced noise in silicon spin qubits, resulting in a more than two-fold (ten-fold) improvement of the inhomogeneous coherence time (Rabi oscillation quality) that leads to a single-qubit gate fidelity of over 99.
View Article and Find Full Text PDFHi-C Calibration by Chemically Induced Chromosomal Interactions.
bioRxiv
December 2024
Department of Biochemistry and Molecular Biology, University Park, PA 16802, USA.
The genome-wide chromosome conformation capture method, Hi-C, has greatly advanced our understanding of genome organization. However, its quantitative properties, including sensitivity, bias, and linearity, remain challenging to assess. Measuring these properties is difficult due to the heterogenous and dynamic nature of chromosomal interactions.
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