The copulatory performance of 18 sexually experienced male rats was tested 30 min after IP injection of the phenylpiperazine, Fluprazine Hydrochloride (4 and 8 mg/kg), or saline solution. Three 20-min tests with an estrous female were conducted at weekly intervals. Each drug dose produced a significant depressive effect on copulatory behavior (latency to and frequency of intromissions and ejaculations) without affecting social investigation. The increased latencies to mounting and intromission observed at both doses suggest that the primary action of the Fluprazine Hydrochloride is to interfere with the transition from social to copulatory patterns. Although the drug's mode of action is currently unknown, the present findings suggest that it operates on some common mediator of sexual and aggressive behavior.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/0091-3057(85)90476-9 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Adipsic, but not anorectic, effect of fluprazine hydrochloride in rats.
Psychopharmacology (Berl)
June 1992
Facultad de Psicología, Universidad Nacional Autónoma de México, Coyoacán, D.F.
The present experiment explored the anorectic and adipsic effects of fluprazine hydrochloride, a phenylpiperazine compound. Thirty-eight albino rats were randomly assigned either to a control saline group (six rats) or to groups (eight subjects each) receiving an IP dose of fluprazine in saline (1.25, 2.
View Article and Find Full Text PDFEffects of eltoprazine hydrochloride on exploratory behavior and social attraction in mice.
Pharmacol Biochem Behav
April 1991
Division of Social Sciences, University of Minnesota-Morris 56267.
The effects of eltoprazine (DU 28853) on exploratory behavior and conspecific social attraction were examined in four experiments. Drug treatments somewhat enhanced three forms of exploratory behavior but decreased social attraction. The results indicate that eltoprazine, in sharp contrast to fluprazine, weakly ameliorates neophobic responses.
View Article and Find Full Text PDFFluprazine hydrochloride: no influence on the odor detection performance of male rats.
Pharmacol Biochem Behav
March 1990
Smell and Taste Center, Hospital of the University of Pennsylvania, Philadelphia 19104.
Fluprazine hydrochloride (DU 27716) decreases copulatory and offensive attack behaviors of male rats and increases their latency to locate buried food in an open field. Since such behaviors are mediated to some degree by the olfactory system, several investigators have hypothesized that this drug may produce an overall impairment in olfactory sensitivity. To test this hypothesis, the influences of five doses of fluprazine hydrochloride (1.
View Article and Find Full Text PDFEffects of fluprazine hydrochloride on maternal behaviour in mice.
Behav Processes
June 2014
Division of Social Sciences, University of Minnesota, Morris, Morris, MN 56267 U.S.A.
Fluprazine hydrochloride treatment disrupted both retrieval and nursing components of maternal behaviour when dam and pups were separated for a 30 min post-infection interval. Subsequent experiments revealed that pup contact during this interval, even when restricted to visual/auditory stimulation, abolished the drug's effect on nursing but not retrieval. Fluprazine appears to strongly and consistently disrupt retrieval while its effects on nursing appear more indirectly mediated.
View Article and Find Full Text PDFEffects of fluprazine hydrochloride on conspecific odor preferences in rats.
Physiol Behav
September 1986
The effect of Fluprazine Hydrochloride (DU 27716) on preference for conspecific male, estrous female and food odors was examined in male rats utilizing a two-compartment choice apparatus. Treatment with 8.0 mg/kg Fluprazine enhanced the preference of males for male odors but had no effect on preference for either estrous female or food odors.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!