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| http://dx.doi.org/10.1136/bmjgh-2023-014067 | DOI Listing |
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Tracking clonal and plasmid transmission in colistin- and carbapenem-resistant .
mSystems
January 2025
Institute for Infection Prevention and Control, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
The surveillance of mobile genetic elements facilitating the spread of antimicrobial resistance genes has been challenging. Here, we tracked both clonal and plasmid transmission in colistin- and carbapenem-resistant using short- and long-read sequencing technologies. We observed three clonal transmissions, all containing Incompatibility group (Inc) L plasmids and New Delhi metallo-beta-lactamase , although not co-located on the same plasmid.
View Article and Find Full Text PDFSpeech correlates of neuropsychiatric symptoms in older adults.
Alzheimers Dement
December 2024
Penn FTD Center, University of Pennsylvania, Philadelphia, PA, USA
Background: Neuropsychiatric symptoms (NPS) including depression and apathy, are common in dementia and profoundly affect both patients and caregivers. These symptoms can manifest early and can be indicative of the disease progression. The existing tools for measuring NPS lack objectivity and are not sensitive enough to detect subtle changes in the earlier stages of dementia.
View Article and Find Full Text PDFIn Situ, High-Resolution Quantification of CO Uptake Rates via Automated Off-Gas Analysis Illuminates Carbon Uptake Dynamics in Cyanobacterial Cultures.
Biotechnol Bioeng
December 2024
School for Engineering of Matter, Transport and Energy, Arizona State University, Tempe, Arizona, USA.
Quantification of cyanobacterial CO fixation rates is vital to determining their potential as industrial strains in a circular bioeconomy. Currently, however, CO fixation rates are most often determined through indirect and/or low-resolution methods, resulting in an incomplete picture of both dynamic behaviors and total carbon fixation potential. To address this, we developed the "Automated Carbon and CO Experimental Sampling System" (ACCESS); a low-cost system for in situ off-gas analysis that supports the automated acquisition of high-resolution volumetric CO uptake rates from multiple cyanobacterial cultures in parallel.
View Article and Find Full Text PDFMapTurns: mapping the structure, H-bonding, and contexts of beta turns in proteins.
Bioinformatics
December 2024
Independent Scientist, Reading, MA 01867, United States.
Motivation: Beta turns are the most common type of secondary structure in proteins after alpha helices and beta sheets and play many key structural and functional roles. Turn backbone (BB) geometry has been classified at multiple levels of precision, but the current picture of side chain (SC) structure and interaction in turns is incomplete, because the distribution of SC conformations associated with each sequence motif has commonly been represented only by a static image of a single, typical structure for each turn BB geometry, and only motifs which specify a single amino acid (e.g.
View Article and Find Full Text PDFIs the shift in treatment patterns towards new, more expensive drugs still driving the increase in pharmaceutical expenditure? A decomposition analysis of expenditure data in Sweden 1990-2022.
Expert Rev Pharmacoecon Outcomes Res
December 2024
Health Economics Unit, Department of Clinical Science (Malmö), Lund University, Lund, Sweden.
Background: Pharmaceutical expenditures (PE) are increasing worldwide, raising concerns about sustainability. However, the current price index provides an incomplete picture of this trend due to the rapid introduction of new drugs on the market.
Objective: The aim of this study is to decompose PE into their components and investigate the development in Sweden from 1990 to 2022.
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