Excitotoxicity-induced cell death in motor neurons is a major therapeutic target for amyotrophic lateral sclerosis (ALS). Yan et al. present a novel compound to specifically disrupt extra-synaptic NMDAR complexes, extending the lifespan of the SOD1 ALS mouse and ameliorating cell death.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10897583 | PMC |
| http://dx.doi.org/10.1016/j.xcrm.2024.101423 | DOI Listing |
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