Proton therapy is an advanced method for treating cancerous tumors, and its adoption has expanded significantly in recent years. The production of high-energy protons, however, may result in the creation of secondary neutrons and gamma rays. Hence, ensuring radiation safety at proton therapy centers is crucial, with shielding playing a vital role. This study aimed to evaluate the efficacy of the shielding implemented at the Provision Proton Therapy center in Knoxville, TN, USA. For this purpose, we measured and compared gamma ray radiation levels within the treatment room and the facility's roof. These measurements were conducted using a NaI(Tl) scintillator detector. The PHITS Monte Carlo code was used to deconvolute the incident spectrum using detector response functions. Findings reveal that the facility's shielding effectively protects the general public from gamma ray radiation, with the effective dose within the treatment room being minimal and dose on the roof was comparable to background radiation levels. However, it is important to note that this study did not address the issue of secondary neutron radiation field, which is an important aspect of dose and radiation safety in proton therapy centers.
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http://dx.doi.org/10.1097/HP.0000000000001796 | DOI Listing |
Langenbecks Arch Surg
January 2025
Department of Visceral, Transplant, Thoracic and Vascular Surgery, Leipzig University Hospital, Leipzig, Germany.
Purpose: Obesity and type 2 diabetes (T2DM) are major risk factors for hepatic steatosis. Diet or bariatric surgery can reduce liver volume, fat content, and inflammation. However, little is known about their effects on liver function, as evaluated here using the LiMAx test.
View Article and Find Full Text PDFDrug Des Devel Ther
January 2025
School of Medicine, Kyungpook National University and Department of Clinical Pharmacology and Therapeutics, Kyungpook National University Hospital, Daegu, 41944, Republic of Korea.
Background: YYD601 is a new dual delayed-release formulation of esomeprazole, developed to enhance plasma exposure and prolong the duration of acid suppression.
Purpose: This study aimed to evaluate the safety, pharmacokinetic (PK), and pharmacodynamic (PD) profiles of YYD601 20 mg following single and multiple oral administrations in healthy, fasting adult Koreans, and to compare these outcomes to those of the conventional esomeprazole 20 mg capsule.
Methods: A randomized, open-label, two-period crossover study was conducted in 28 participants, who were divided into two treatment groups: one group received YYD601 20 mg, and the other received conventional esomeprazole 20 mg, once daily for five consecutive days.
Background/objectives: Bone marrow (BM) adipocytes are critical in progressing solid tumor metastases and hematological malignancies across pediatric to aging populations. Single-point biopsies remain the gold standard for monitoring BM diseases, including hematologic malignancies, but are limited in capturing the full complexity of loco-regional and global BM microenvironments. Non-invasive imaging techniques like Magnetic Resonance Imaging (MRI), could offer valuable alternatives for real-time evaluation of BM diseases in both preclinical translational and clinical studies.
View Article and Find Full Text PDFPhys Imaging Radiat Oncol
October 2024
Aarhus University Hospital, Danish Centre for Particle Therapy, Aarhus N, Denmark.
Background And Purpose: Radiotherapy for paediatric posterior fossa tumours may cause complications in the brainstem and upper spinal cord due to high doses. With proton therapy (PT) this risk may increase due to higher relative biological effectiveness (RBE) from elevated linear energy transfer (LET). This study assesses variations in LET in the brainstem and spinal cord in proton treatment plans from European centres.
View Article and Find Full Text PDFAdv Radiat Oncol
February 2025
Department of Advanced Radiation Oncology and Proton Therapy, Inova Schar Cancer Institute, Fairfax, Virginia.
Purpose: This study evaluates the hypothesis that a volumetric skin-sparing planning technique (SSPT) will reduce acute dermatitis in patients treated to the breast or chest wall (CW) with proton pencil-beam scanning (PBS).
Methods And Materials: In January 2022, our center incorporated volumetric-based skin-sparing objectives in addition to skin hot spot evaluation as an SSPT. The SSPT incorporated an objective to limit the volume of a skin evaluation structure (skin-eval) receiving 95% of the prescription dose or more (V95%Rx) to ideally < 50%.
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