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Engineered biomimetic cisplatin-polyphenol nanocomplex for chemo-immunotherapy of glioblastoma by inducing pyroptosis.
J Nanobiotechnology
January 2025
Department of Pharmacy The Second Xiangya Hospital, Central South University, Changsha, 410011, China.
Glioblastoma multiforme (GBM) is characterized by pronounced immune escape and resistance to chemotherapy-induced apoptosis. Preliminary investigations revealed a marked overexpression of gasdermin E (GSDME) in GBM. Notably, cisplatin (CDDP) demonstrated a capacity of inducing pyroptosis by activating caspase-3 to cleave GSDME, coupled with the release of proinflammatory factors, indicating the potential as a viable approach of inducing anti-tumor immune activation.
View Article and Find Full Text PDFUltrasound-guided femoral nerve block reduced the incidence of postoperative delirium after total knee arthroplasty: A double-blind, randomized study.
Medicine (Baltimore)
November 2024
Department of Anesthesiology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, China.
Background: Postoperative delirium (POD) is an acute brain dysfunction that mainly occurs in elderly patients after surgery. Postoperative pain is an important factor in the occurrence of POD, and effective pain management can reduce the risk of POD. Our study aims is to investigate the effect of ultrasound-guided femoral nerve block (FNB) on postoperative pain and the occurrence of POD after knee arthroplasty, and whether its mechanism is related to oxidative stress, inflammatory factors.
View Article and Find Full Text PDFThe Landscape of Experimental Cardiac Arrest Research Models in Rats: A Bibliometric Analysis of the 100 Most Cited Articles.
Clin Exp Emerg Med
January 2025
Department of Emergency Medicine, Faculty of Medicine, School of Health Sciences, University of Thessaly, 41500, Viopolis, Larissa, Greece.
This study aimed to conduct a bibliometric analysis of the 100 most cited articles on experimental cardiac arrest models in rats, identifying key contributors, publication trends, research themes, and collaboration networks. A comprehensive literature search was performed on the Web of Science (WoS) database on June 11, 2024, using keywords related to cardiac arrest and rat models. The top 100 most cited articles were analyzed using the Biblioshiny web application from the Bibliometrix R package (version 4.
View Article and Find Full Text PDFImpact of dexmedetomidine-ropivacaine versus sufentanil-ropivacaine combination for epidural labour analgesia on neonatal outcomes: a pilot randomised clinical trial.
BMJ Open
December 2024
Department of Anesthesiology, Peking University First Hospital, Beijing, China
Objective: To investigate the impact of dexmedetomidine-ropivacaine combination versus sufentanil-ropivacaine combination for epidural labour analgesia on neonatal and maternal outcomes and test the feasibility of a future large, randomised trial.
Design: A randomised, double-blind, pilot clinical trial from 16 March 2023 to 15 June 2023.
Setting: A tertiary-care hospital in Beijing, China.
A Case Report on an Unknown Etiology Disorder of Consciousness Following Extubation Despite Thorough Evaluation.
Cureus
December 2024
Anesthesiology, Showa University School of Medicine, Tokyo, JPN.
Postoperative disorders of consciousness can arise from various factors, making diagnosis challenging. This report presents a case of a disorder of consciousness that occurred after awakening from general anesthesia, in which various examinations including computed tomography (CT) and magnetic resonance imaging (MRI) were conducted, but the cause could not be identified. A man in his 60s with a history of hypertension and cerebral hemorrhage underwent revision total hip arthroplasty under general anesthesia for a left periprosthetic hip fracture.
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