Centriolar appendages evolve into the inner sheath of mammalian flagella.

J Cell Biol

State Key Laboratory of Reproductive Medicine and Offspring Health, The Affiliated Taizhou People's Hospital of Nanjing Medical University, Taizhou School of Clinical Medicine, Nanjing Medical University, Nanjing, China.

Published: March 2024

The annulus, a septin-based structure in vertebrate sperm connecting the MP and PP, has unclear migration mechanics. In this issue, Hoque et al. (https://doi.org/10.1083/jcb.202307147) report that the CBY3/CIBAR1 complex ensures its precise positioning by regulating membrane properties.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10880463PMC
http://dx.doi.org/10.1083/jcb.202401149DOI Listing

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