New chemotherapeutics are urgently required to treat infections caused by drug-resistant strains. The effects of 16 1,10-phenanthroline (phen)/1,10-phenanthroline-5,6-dione/dicarboxylate complexed with Mn(II), Cu(II) and Ag(I) were evaluated against ten different species. Proliferation of , , , , , , , , and was inhibited by three of six Cu(II) (MICs 1.52-21.55 μM), three of three Ag(I) (MICs 0.11-12.74 μM) and seven of seven Mn(II) (MICs 0.40-38.06 μM) complexes. Among these [Mn(oda)(phen)(HO)][Mn(oda)(phen)(oda)].4HO, where oda = octanedioic acid, exhibited effective growth inhibition (MICs 0.4-3.25 μM), favorable activity indexes, low toxicity against Vero cells and good/excellent selectivity indexes (46.88-375). [Mn(oda)(phen)(HO)][Mn(oda)(phen)(oda)].4HO represents a promising chemotherapeutic option for emerging, medically relevant and drug-resistant species.
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