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Melanoma immunotherapy enabled by M2 macrophage targeted immunomodulatory cowpea mosaic virus. | LitMetric
We have developed nanoparticle formulations targeting M2 macrophages for cancer immunotherapy by conjugating high-affinity binding peptides to cowpea mosaic virus as an immunostimulatory adjuvant. We confirmed the targeting of and uptake by M2 macrophages and the therapeutic efficacy of the nanoparticles against murine melanoma .
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