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http://dx.doi.org/10.1186/s13287-024-03662-yDOI Listing

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SPARC, a matricellular protein: at the crossroads of cell-matrix communication.

Matrix Biol

January 2001

The Department of Vascular Biology, The Hope Heart Institute, 1124 Columbia St., Seattle, WA 98104, USA.

SPARC is a multifunctional glycoprotein that belongs to the matricellular group of proteins. It modulates cellular interaction with the extracellular matrix (ECM) by its binding to structural matrix proteins, such as collagen and vitronectin, and by its abrogation of focal adhesions, features contributing to a counteradhesive effect on cells. SPARC inhibits cellular proliferation by an arrest of cells in the G1 phase of the cell cycle.

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