AI Article Synopsis

  • * The timeline of infections post-transplant indicates that bacterial infections dominate initially, with viral and fungal infections becoming more prevalent later, and opportunistic infections usually occurring within the first 6 months.
  • * To effectively manage infection risks, it is essential to consider factors like time since transplant, patient history, and local infection trends, leading to a need for tailored regional guidelines for screening and prevention.

Article Abstract

Kidney transplant often is complicated by infections in the recipient from therapy-related and patient-related risk factors. Infections in kidney transplant recipients are associated with increased morbidity, mortality, and allograft dysfunction. There is a predictable timeline after kidney transplant regarding the types of pathogens causing infections, reflecting the net state of immunosuppression. In the early post-transplant period, bacterial infections comprise two thirds of all infections, followed by viral and fungal infections. Infections occurring early after kidney transplantation are generally the result of postoperative complications. In most cases, opportunistic infections occur within 6 months after kidney transplantation. They may be caused by a new infection, a donor-derived infection, or reactivation of a latent infection. Community-acquired pneumonia, upper respiratory tract infections, urinary tract infections, and gastrointestinal infections are the most common infections in the late period after transplantation when the net immunosuppression is minimal. It is crucial to seek information on the time after transplant, reflecting the net state of immunosuppression, previous history of exposure/infections, geography, and seasonal outbreaks. It is imperative that we develop regionally specific guidelines on screening, prevention, and management of infections after kidney transplantation.

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.semnephrol.2023.151486DOI Listing

Publication Analysis

Top Keywords

kidney transplantation
16
infections
14
infections kidney
12
kidney transplant
12
reflecting net
8
net state
8
state immunosuppression
8
tract infections
8
kidney
7
transplantation
5

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!