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Pharmacokinetic/pharmacodynamic issues for optimizing treatment with beta-lactams of Gram-negative infections in critically ill orthotopic liver transplant recipients: a comprehensive review.
Front Antibiot
June 2024
Department of Medical and Surgical Sciences, Alma Mater Studiorum University of Bologna, Bologna, Italy.
Orthotopic liver transplant (OLT) represents the standard of care for managing patients affected by end-stage and life-threatening liver diseases. Although a significant improvement in surgical techniques, immunosuppressant regimens, and prompt identification of early post-transplant complications resulted in better clinical outcome and survival in OLT recipients, the occurrence of early bacterial infections still represents a remarkable cause of morbidity and mortality. In this scenario, beta-lactams are the most frequent antimicrobials used in critical OLT recipients.
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Theranostics, Theragnostics, or Iama-gnostics?
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Retired Consultant Medical Oncologist , Formerly, Charing Cross Hospital, London, U.K.
Many reputable medical journals, including The Lancet and the BMJ, have adopted the term "Theranostics". Under the alternative term "Theragnostics", PubMed currently registers 1207 articles. Both terms encountered by the reader for the first time are puzzling and largely meaningless, if not confusing.
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