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Joint analysis of blood pressure changes over time and survival of hypertensive patients under treatment at Sawula hospital in Southern Ethiopia.
BMC Public Health
January 2025
Department of Statistics, Borana University, Borena, Oromia Region, Ethiopia.
Introduction: Hypertension is among the most significant non-communicable public health issues worldwide. High blood pressure, or hypertension, has been associated with severe health consequences, including death, aneurysms, stroke, chronic renal disease, eye damage, heart attack, heart failure, peripheral artery disease, and vascular dementia. Consequently, this study aimed to investigate the predictors linked to survival time and the progression of blood pressure measurements in hypertensive patients.
View Article and Find Full Text PDFA Case of Problem-Free Survival Five Years After Abdominal Aortic Sigmoid Colon Fistula Surgery.
Cureus
December 2024
Cardiovascular Surgery, Sapporo Medical University, Sapporo, JPN.
An a (AEF) is a rare but life-threatening condition where an abnormal connection forms between the aorta and the gastrointestinal tract, most commonly the duodenum. It can be primary (arising spontaneously due to an aortic aneurysm or infection) or secondary (complicating prior vascular surgery). Immediate recognition and surgical intervention are critical to manage severe gastrointestinal bleeding and prevent fatal outcomes.
View Article and Find Full Text PDFLIM kinases in cardiovascular health and disease.
Front Physiol
December 2024
NextGen Precision Health, University of Missouri, Columbia, MO, United States.
The Lim Kinase (LIMK) family of serine/threonine kinases is comprised of LIMK1 and LIMK2, which are central regulators of cytoskeletal dynamics via their well-characterized roles in promoting actin polymerization and destabilizing the cellular microtubular network. The LIMKs have been demonstrated to modulate several fundamental physiological processes, including cell cycle progression, cell motility and migration, and cell differentiation. These processes play important roles in maintaining cardiovascular health.
View Article and Find Full Text PDFBig data analytics and scRNA-seq in human aortic aneurysms and dissections: role of endothelial MerTK.
Theranostics
January 2025
Department of Biology, Georgia State University, Atlanta, GA, 30303, USA.
Article Synopsis
- Aortic aneurysms and dissections (AAD) lead to over 10,000 deaths annually in the U.S., and currently, there are no effective medications to prevent them.
- Researchers focused on ascending aortic aneurysms and dissections (AAAD) and explored the role of the MerTK receptor in endothelial cells as it relates to AAAD progression.
- Utilizing advanced techniques like single-cell RNA sequencing and a specific mouse model lacking MerTK in endothelial cells, the study found that MerTK deficiency significantly increases the risk of AAAD by causing endothelial dysfunction and changes in smooth muscle cell behavior.
Multiple intrahepatic artery aneurysms during the treatment for IgG4-related sclerosing cholangitis: A case report.
World J Hepatol
December 2024
Division of Gastroenterology and Hepatology, Department of Internal Medicine, Faculty of Medicine, University of Miyazaki, Miyazaki 889-1692, Japan.
Article Synopsis
- The case report discusses a 64-year-old woman with IgG4-related sclerosing cholangitis who developed multiple intrahepatic artery aneurysms while on treatment.
- Emergency procedures successfully treated the aneurysms, resolving her symptoms and stabilizing her condition.
- The report highlights that hepatic artery aneurysms can be serious complications in patients with IgG4-SC, indicating a need for vigilant monitoring.
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