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Suppression of TLR4/NF-κB signaling by kaurenoic acid in a mice model of monosodium urate crystals-induced acute gout.
Arch Biochem Biophys
January 2025
Pharmacological Sciences Research Lab, Department of Pharmacy, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan; Department of Pharmacy, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan. Electronic address:
Aim: The aim of the current study was to investigate the potential therapeutic effect of kaurenoic acid (KA) against Monosodium Urate Crystals (MSU)- induced acute gout by downregulation of NF-κB signaling pathway, mitigating inflammation and oxidative stress produced by MSU crystals. KA potentially targeted NF-κB pathway activation and provided comprehensive insights through multiple approaches. This was accomplished by advanced analytical techniques.
View Article and Find Full Text PDFComparison of complications and surgery outcomes in skin closure methods following cesarean sections.
Arch Gynecol Obstet
January 2025
Department of Obstetrics and Gynecology, Lis Hospital for Women's Health, Tel Aviv Sourasky Medical Center, Tel Aviv University, Tel Aviv, Israel.
Purpose: This study aimed to assess the impact of absorbable subcutaneous staples for skin closure in cesarean delivery (CD) on maternal morbidity.
Methods: A retrospective cohort study was conducted at a single tertiary university-affiliated medical center between January 2011 and April 2022. In 2020, a new technique involving absorbable subcutaneous staples for skin closure in CD was introduced.
Comparison of Long-Term Antibody Titers in Calves Treated with Different Conjunctival and Subcutaneous S19 Vaccines.
Animals (Basel)
January 2025
Department of Microbiology, Faculty of Veterinary Medicine, Selcuk University, 42130 Konya, Turkey.
Brucellosis is still the most common zoonosis worldwide despite advanced technology and animal husbandry. Since there is still no effective vaccine for humans, it is crucial to control the disease in ruminants through eradication and vaccination. Although some countries around the world have achieved this circumstance, every country aims to become free of Brucellosis through vaccination, animal movements, and various eradication measures.
View Article and Find Full Text PDFAPPLICATION OF IMPROVED AUTODERMOPLASTY TECHNIQUE IN GRANULATING WOUNDS TREATMENT.
Georgian Med News
November 2024
1Department of Hospital Surgery, Anesthesiology and Reanimatology, Non-Commercial Joint-Stock Company "Semey Medical University" (NCJSC "SMU"), Republic of Kazakhstan.
Unlabelled: This prospective study was conducted at the Department of Surgery of the Pavlodar branch of the NCJSC "SMU" (Non-profit joint-stock company "Medical University of Semey" based on the city hospital No. 1, surgical hospital of Pavlodar, Kazakhstan.
Purpose: The purpose of research is to evaluate the results of improved autodermoplasty technique for granulating wounds of different origin.
Reference Values for Water-Specific T1, Intermuscular and Intramuscular Fat Content in Skeletal Muscle at 2.89 T.
J Magn Reson Imaging
January 2025
Department of Biomedical Engineering, University of Alberta, Edmonton, Alberta, Canada.
Background: MRI offers quantification of proton density fat fraction (PDFF) and tissue characteristics with T1 mapping. The influence of age, sex, and the potential confounding effects of fat on T1 values in skeletal muscle in healthy adults are insufficiently known.
Purpose: To determine the accuracy and repeatability of a saturation-recovery chemical-shift encoded multiparametric approach (SR-CSE) for quantification of T1 and muscle fat content, and establish normative values (age, sex) from a healthy cohort.
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