The MiniMed™ 780G advanced hybrid closed-loop system (MM780G) builds on the basal automation and low-glucose protection features of the MiniMed™ 670G and 770G systems. While previous publications have focused on glycemic control improvements with MM780G, burden reduction has not been fully described. Data from two 3-month pivotal trials for the MM670G with Guardian™ Sensor 3 (GS3) (104 adults; 125 children) and MM780G with Guardian™ 4 Sensor (G4S) (67 adults;109 children) were compared. Real-world data (RWD) from United States users ( = 3851) transitioning from MM770G+GS3 to MM780G+G4S were also analyzed. Analyses included a new metric for diabetes management burden (i.e., pentagon composite metric), glycemic outcomes and system burden (e.g., closed-loop exits and fingersticks per day). Diabetes burden metric (-22.8% and -28.5%), time in range (+3.1% [* = 0.035] and +6.4% [ < 0.001]) and time below range (-1.8% [* < 0.001] and -0.7% [* < 0.001]) significantly improved, compared to MM670G for adult and pediatric participants, respectively. The pediatric mean sensor glucose (SG) reduced by -8.6 mg/dL (* < 0.001), while the adults' saw no change. Closed-loop use significantly increased for both cohorts (+17.1% [* < 0.001] and +20.5% [* < 0.001]). Closed-loop exits were significantly reduced to about 1 per week (-0.5 [* < 0.001] and -0.7 [* < 0.001]); fingerstick tests were also reduced (-6.2 [* < 0.001] and -6.9 [* < 0.001]). Similar outcomes were observed from U.S. RWD. MiniMed™ 780G with G4S use was associated with significant reduction in diabetes management burden with fewer closed-loop exits, fingersticks and other interactions, and improvements in glycemic control when compared to the MiniMed™ 670G with GS3.
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http://dx.doi.org/10.1089/dia.2023.0459 | DOI Listing |
Background: The geroscience hypothesis posits that aging biological processes contribute to many age-related deficits, including the accumulation of multiple chronic diseases. Though only one facet of mitochondrial function, declines in muscle mitochondrial bioenergetic capacities may contribute to this increased susceptibility to multimorbidity.
Methods: The Study of Muscle, Mobility and Aging (SOMMA) assessed muscle mitochondrial energetics in 764 older adults (mean age =76.
Int Ophthalmol Clin
January 2025
Retina Health Institute, Algonquin, IL.
Tyrosine kinase inhibitors (TKIs) serve to inhibit the phosphorylation cascade that usually leads to abnormal processes such as vascular leakage and tumorigenesis. Within retinal diseases specifically, dysregulation of the vascular endothelial growth factor receptor tyrosine kinases can lead to age-related macular degeneration and diabetic macular edema. These diseases have a growing prevalence and are leading causes of vision loss.
View Article and Find Full Text PDFKidney Int
December 2024
Department of Medical Statistics, London School of Hygiene & Tropical Medicine, London, UK.
The disadvantaged populations eGFR (estimated glomerular filtration rate) epidemiology (DEGREE) study was designed to gain insight into the burden of chronic kidney disease (CKD) of undetermined cause (CKDu) using standard protocols to estimate the general-population prevalence of low eGFR internationally. Therefore, we estimated the age-standardized prevalence of eGFR under 60 ml/min per 1.73m in adults aged 18-60, excluding participants with commonly known causes of CKD; an ACR (albumin/creatinine ratio) over 300 mg/g or equivalent, or self-reported or measured (HT) hypertension or (DM) diabetes mellitus, stratified by sex and location.
View Article and Find Full Text PDFBiochem Biophys Res Commun
December 2024
Department of Endocrinology and Metabolism, The Affiliated Hospital of Qingdao University, Qingdao, China; Qingdao Key Laboratory of Thyroid Diseases, Medical Research Cente, Qingdao, China. Electronic address:
Diabetic nephropathy (DN) is one of the most severe kidney complications and the primary contributor to end-stage renal disease on a global scale. It exacerbates the morbidity, mortality, and financial burden for individuals with diabetes. Isoquercitrin, a natural compound found in various plants, has demonstrated potential as an antidiabetic agent.
View Article and Find Full Text PDFJ Clin Periodontol
December 2024
National Dental Research Institute Singapore, National Dental Centre Singapore, Singapore, Singapore.
Aim: To estimate the causal effects of smoking and cessation on tooth loss using instrumental variable (IV) analysis.
Material And Methods: Data from the Behavioural Risk Factor Surveillance System (BRFSS), conducted from 1995 to 2006, 2008, 2010, and 2012 in 50 U.S.
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