Rheumatoid arthritis (RA), a prevalent chronic disease, poses significant treatment challenges, including side effects and high costs of conventional therapies. This heightens interest in natural, over-the-counter (OTC) anti-inflammatory supplements as potential adjunctive treatments. Given their roles in mitigating inflammation and oxidative stress, key factors in RA pathogenesis, these supplements could offer valuable therapeutic adjunctive. Our review addresses this emerging area, providing insights into the efficacy and safety of these supplements in RA management. Methods: observational studies, systematic reviews, and meta-analyses on anti-inflammatory supplements in RA over the past 10 years. Relevant articles were reviewed, and data was synthesized. Several supplements demonstrate beneficial anti-inflammatory and antioxidant properties that may improve RA outcomes. Quercetin suppresses inflammatory cytokines and pathways. Green tea polyphenols inhibit mediators like TNF-alpha and IL-6. Curcumin impacts inflammatory cytokines and signaling cascades. Ginger components block enzymes and inflammation pathways. Omega-3 fatty acids modulate immune cell function and cytokine production. While promising, high-quality evidence remains limited, and optimal dosing is uncertain for most supplements. Our review emphasizes the potential of over-the-counter anti-inflammatory supplements as an adjunctive treatment in rheumatoid arthritis. While these supplements, like quercetin, green tea polyphenols, and omega-3 fatty acids, show promising anti-inflammatory and immunomodulatory effects, there are substantial concerns regarding their consistency and quality in the market, unclear interactions with conventional medications, and the lack of standardized dosages. More extensive research, particularly randomized controlled trials, is crucial to establish clear guidelines.
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http://dx.doi.org/10.14336/AD.2024.0131 | DOI Listing |
Nutrients
December 2024
IFF, Health & Biosciences, Sokeritehtaantie 20, 02460 Kantvik, Finland.
Background/objectives: Ergothioneine (EGT) is an effective antioxidant that animals cannot produce and has an important anti-inflammatory role in cell protection, which can help lower the risk of various diseases. In this study, we investigated the potential role of gut microbiota in the production of EGT, which was found to increase in the mouse liver after dietary supplementation with betaine (BET) or polydextrose (PDX).
Methods: The effects of BET and PDX on the gut microbiota and tissue EGT content were investigated using a diet-induced obese mouse model and simulated fermentation in the human colon.
Nutrients
December 2024
Department of Experimental and Clinical Medicine, University of Florence, 50134 Firenze, Italy.
Metabolic alterations, including hypermetabolism, lipid imbalances, and glucose dysregulation, are pivotal contributors to the onset and progression of Amyotrophic Lateral Sclerosis (ALS). These changes exacerbate systemic energy deficits, heighten oxidative stress, and fuel neuroinflammation. Simultaneously, gastrointestinal dysfunction and gut microbiota (GM) dysbiosis intensify disease pathology by driving immune dysregulation, compromising the intestinal barrier, and altering gut-brain axis (GBA) signaling, and lastly advancing neurodegeneration.
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December 2024
Department of Nephrocardiology, Medical University of Lodz, 90-549 Lodz, Poland.
This narrative review explores the benefits and risks of cannabinoids in kidney health, particularly in individuals with pre-existing renal conditions. It discusses the roles of cannabinoid receptor ligands (phytocannabinoids, synthetic cannabinoids, and endocannabinoids) in kidney physiology. The metabolism and excretion of these substances are also highlighted, with partial elimination occurring via the kidneys.
View Article and Find Full Text PDFNutrients
December 2024
Department of Immunopathology, Faculty of Medicine, Medical University of Lodz, Zeligowskiego 7/9, 90-752 Lodz, Poland.
Asthma (a chronic inflammatory disease of the airways) is characterized by a variable course, response to treatment, and prognosis. Its incidence has increased significantly in recent decades. Unfortunately, modern lifestyle and environmental factors contribute to the further increase in the incidence of this disease.
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December 2024
Key Laboratory of Ecology and Environment in Minority Areas (Minzu University of China), National Ethnic Affairs Commission of China, Beijing 100081, China.
(Hua) Engl. ex K. Krause, locally known as (bitter greens) or , is a widely consumed wild vegetable and traditional herbal medicine in western Yunnan.
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