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Osteochondral Tissue Engineering: Scaffold Materials, Fabrication Techniques and Applications.
Biotechnol J
January 2025
Cancer Hospital of Dalian University of Technology, Dalian R&D Center for Stem Cell and Tissue Engineering, Dalian University of Technology, Dalian, China.
Osteochondral damage, caused by trauma, tumors, or degenerative diseases, presents a major challenge due to the limited self-repair capacity of the tissue. Traditional treatments often result in significant trauma and unpredictable outcomes. Recent advances in bone/cartilage tissue engineering, particularly in scaffold materials and fabrication technologies, offer promising solutions for osteochondral regeneration.
View Article and Find Full Text PDFFluoride Exposure Modulates Skeletal Development and Mineralization in Zebrafish Larvae.
Environ Toxicol
January 2025
Molecular Toxicology Laboratory, Department of Biotechnology, Bharathiar University, Coimbatore, Tamil Nadu, India.
The presence of high levels of fluoride (F) in groundwater is a major issue worldwide. Although F is essential for healthy teeth and bones, excessive exposure can cause fluorosis or F toxicity. This condition primarily affects the hard tissues due to their high F retention capacity.
View Article and Find Full Text PDFAnalysis of MRI-based vertebral bone quality (VBQ) scores in patients with degenerative lumbar scoliosis.
World Neurosurg
January 2025
Department of Radiology, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, 200071, P.R. China.
Introduction: Degenerative lumbar scoliosis (DLS) often causes various issues such as neural symptoms and osteoporosis (OP). Vertebral bone quality (VBQ) is a crucial factor that surgeons take into consider prior to surgery. However, little attention has been given to the use of VBQ in evaluating vertebral bone mass in DLS patients.
View Article and Find Full Text PDFBio-inspired mineralized collagen scaffolds with precisely controlled gradients for the treatment of severe osteoarthritis in a male rabbit model.
Int J Biol Macromol
January 2025
State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, PR China; Gansu Engineering Research Center of Medical Collagen, Lanzhou 730000, PR China. Electronic address:
Osteoarthritis affects approximately 500 million individuals globally, with severe cases often leading to osteochondral defects. Biomimetic collagen-hydroxyapatite scaffolds have been investigated for the treatment of osteochondral defects. However, achieving precise mimicry of the intricate composition, gradient nanostructure, and biological function of native tissue remains a formidable challenge.
View Article and Find Full Text PDFIntroduction: Zinc, an essential trace element, plays an important role in various cellular processes, and zinc deficiency is common in patients undergoing hemodialysis. Zinc has been shown to stimulate osteoblastic bone formation and mineralization and inhibit osteoclastic bone resorption. Although osteoporosis is highly prevalent among patients undergoing hemodialysis, the utility of areal bone mineral density (aBMD) measured using dual-energy X-ray absorptiometry (DXA) is limited because DXA cannot reveal bone microarchitectural alterations.
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