AI Article Synopsis
- Safe and accurate delivery of biocompatible materials is essential for biomedical applications like drug release and tissue restoration, but current invasive methods pose risks such as infections and long healing times.
- A novel non-invasive method using acousto-sensitive materials allows for targeted delivery deep into the body by using ultrasound to polymerize materials without additional components.
- This technology not only enables controlled drug release and functional cell delivery but also allows for customization of material properties, paving the way for a new approach in clinical applications and 3D printing techniques, termed "acousto-printing."
Article Abstract
Safe and accurate in situ delivery of biocompatible materials is a fundamental requirement for many biomedical applications. These include sustained and local drug release, implantation of acellular biocompatible scaffolds, and transplantation of cells and engineered tissues for functional restoration of damaged tissues and organs. The common practice today includes highly invasive operations with major risks of surgical complications including adjacent tissue damage, infections, and long healing periods. In this work, a novel non-invasive delivery method is presented for scaffold, cells, and drug delivery deep into the body to target inner tissues. This technology is based on acousto-sensitive materials which are polymerized by ultrasound induction through an external transducer in a rapid and local fashion without additional photoinitiators or precursors. The applicability of this technology is demonstrated for viable and functional cell delivery, for drug delivery with sustained release profiles, and for 3D printing. Moreover, the mechanical properties of the delivered scaffold can be tuned to the desired target tissue as well as controlling the drug release profile. This promising technology may shift the paradigm for local and non-invasive material delivery approach in many clinical applications as well as a new printing method - "acousto-printing" for 3D printing and in situ bioprinting.
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| http://dx.doi.org/10.1002/smtd.202301197 | DOI Listing |
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