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| http://dx.doi.org/10.1111/tid.14232 | DOI Listing |
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Impact of Copper(II) and Silver(I) Complexes Containing 1,10-Phenanthroline-5,6-dione on Cellular and Virulence Aspects of Scedosporium apiospermum.
Curr Top Med Chem
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Laboratório de Estudos Avançados de Microrganismos Emergentes e Resistentes (LEAMER), Departamento de Microbiologia Geral, Instituto de Microbiologia Paulo de Góes (IMPG), Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil.
Background: Scedosporium apiospermum is a multidrug-resistant filamentous fungus that causes localized and disseminated diseases. Our group has previously described that metalbased complexes containing copper(II) or silver(I) ions complexed with 1,10-phenanthroline-5,6- dione (phendione) inhibited the viability of S. apiospermum conidial cells.
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Departments of Pathobiology, College of Veterinary Medicine, Auburn University, Auburn, AL, USA.
A 2-y-old, intact female, mixed-breed dog was presented to the veterinary hospital with abdominal distension, anemia, and lethargy following a chronic history of nonspecific gastrointestinal signs. CBC and serum biochemistry revealed moderate nonregenerative anemia with neutrophilia, hypoalbuminemia, hyperglobulinemia, hypoglycemia, decreased urea and creatinine, and hypercholesterolemia. Abdominal radiographs and ultrasound revealed a large heterogeneous mesenteric mass and ascites.
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BMC Neurol
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Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Article Synopsis
- Scedosporium apiospermum is a rare fungal pathogen that typically affects immunocompromised individuals and is associated with poor outcomes.
- A 37-year-old woman developed multiple lesions in her lungs, brain, and eyes after a near drowning incident, leading to confirmed S. apiospermum infection through advanced genomic sequencing.
- Despite treatment with voriconazole, the patient experienced significant improvement but unfortunately lost vision in one eye due to a delayed diagnosis, highlighting the need for prompt recognition and intervention even in otherwise healthy individuals.
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