AI Article Synopsis
- Flucloxacillin can cause serious low potassium levels (hypokalaemia) that may worsen even with potassium supplements.
- After starting high doses of flucloxacillin for a patient with an infected knee replacement, hypokalaemia was observed, and the patient did not respond well to potassium treatment.
- The solution involved switching antibiotics and increasing potassium, which improved the patient's condition, highlighting the need to monitor potassium levels when prescribing flucloxacillin.
Article Abstract
Flucloxacillin-induced hypokalaemia can be progressive and life-threatening, despite of potassium supplementation. In this case description, a high dose of intravenous flucloxacillin was started after a 68-year-old patient presented with an infected knee replacement. After two days, hypokalaemia was noted with an inadequate response to potassium supplementation. It was decided to change antibiotics and increase potassium supplementation, with good results. It is advisable to include monitoring of potassium levels in local treatment protocols when flucloxacillin is prescribed.
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