Effect of romosozumab in premenopausal women with severe osteoporosis and anorexia nervosa.

Osteoporos Sarcopenia

Department of Orthopaedic Surgery, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba, 260-8670, Japan.

Published: December 2023

Objectives: This study aims to investigate the effects of romosozumab on bone mineral density (BMD) and bone metabolism.

Methods: In this retrospective case series, romosozumab was administered to 5 premenopausal female patients with osteoporosis and anorexia nervosa with fragility fractures. BMD and bone turnover marker changes were investigated at 6 months and 1 year after administering romosozumab.

Results: BMD increased and high-turnover bone metabolism decreased 6 months and 1 year after administering romosozumab.

Conclusions: Romosozumab is useful for treating osteoporosis in patients with anorexia nervosa.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10874744PMC
http://dx.doi.org/10.1016/j.afos.2023.10.001DOI Listing

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