A new isopimarane-type diterpene with anti-inflammatory activity from the .

A new isopimarane-type diterpene clinacanoid A () together with seven known terpenoids () were obtained from the . Their structures were elucidated based on extensive spectroscopic analysis (NMR, HR-ESI-MS), and the absolute configuration of was established based on single crystal X-ray diffraction. The inhibitory activity of all the compounds on NO production in lipopolysaccharide-induced (LPS) mouse leukemic monocyte macrophage RAW264.7 cells was evaluated. Among them, compounds and showed potential anti-inflammatory activities, with IC values of 13.3 ± 0.3 and 12.4 ± 0.4 M, respectively.