In this study, a modular approach toward cyclic sulfoximines and sulfondiimines via palladium-catalyzed intramolecular C-H/C-C activation reactions was reported. Various 1,2-benzothiazines including bicyclic, tricyclic, highly fused ones, ones of the seven-membered ring, along with 1,2-benzothiazine 1-imines were accessed in good yields. KIE experiment demonstrated that the C-H bond cleavage at the position to the sulfoximine group is not the rate-determining step in the coupling reaction.
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Investigations on 5,6,7,8-tetrahydro-[1,2,4]triazolo[1,2-]pyridazin-1-amines and related compounds: synthesis, chemical behaviour, structure elucidation and iNOS inhibitory activity.
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Article Synopsis
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J Org Chem
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Guangxi Key Laboratory of Natural Polymer Chemistry and Physics, College of Chemistry and Materials, Nanning Normal University, Nanning 530001, P. R. China.
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Department of Chemistry, SRM University AP, Amaravati, Andhra Pradesh, 522502, India.
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