This article introduces a reductive coupling driven by visible-light, facilitating the synthesis of pyridine-substituted alcohols and amines through the reaction of aldehydes, ketones and imines with cyanopyridines. Hantzsch esters serve as reductants in this process, eliminating the need for transition-metals or photosensitizers. The method demonstrates extensive compatibility and finds utility in the late-stage functionalization of both natural and pharmaceutical products, offering a sustainable pathway for the diversification of chemical compounds.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1039/d4cc00044g | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
The Impact of Psychological Insulin Resistance and Dyadic Coping on Insulin Medication Adherence in Elderly Diabetes Patients and Their Spouses: A Latent Profile Analysis.
Patient Prefer Adherence
December 2024
College of Nursing, Yanbian University, Yanji, People's Republic of China.
Aim: To investigate the characteristics of psychological insulin resistance and dyadic coping in elderly diabetic patients and their spouses, and their association with insulin medication adherence.
Design: Observational, cross-sectional study.
Methods: A convenience sampling method selected 300 elderly diabetic patient-spouse pairs from a community.
Electrochemical Dicarboxylation of Vinyl Epoxide with CO2 for the Facile and Selective Synthesis of Diacids.
Angew Chem Int Ed Engl
December 2024
East China Normal University, School of Chemistry and Molecular Engineering, 3663 N. Zhongshan Rd., 200062, Shanghai, CHINA.
We present a novel electrochemical dicarboxylation of epoxides with CO2, characterized by the cleavage of two C-O single bonds. Not only are vinyl epoxides viable, but cyclic carbonates also serve as effective substrates, facilitating the synthesis of E-configured adipic and octanedioic acids with high chemo-, regio-, and stereoselectivity. The synthetic practicality is further highlighted by the diverse functionalizations of the resulting multifunctional diacids.
View Article and Find Full Text PDFPhotoinduced Reductive C-O Couplings from Unsymmetrical Bis-Cyclometalated Pt(IV) Dicarboxylato Complexes.
Inorg Chem
December 2024
Departamento de Química Inorgánica, Facultad de Química, Universidad de Murcia, Campus de Espinardo 19, Murcia 30100, Spain.
Unsymmetrical bis-cyclometalated dicarboxylato complexes (-6-32)-[Pt(tpy)(OCR)] [tpy = cyclometalated 2-(-tolyl)pyridine, R = -Bu (), Me (), Ph (), CF ()], are obtained from the reaction of -[Pt(tpy)] with the appropriate PhI(OCR) reagent. Treatment of complexes of this type with different carboxylates (R'CO) results in the formation of mixed-carboxylato derivatives, namely (-6-43)-[Pt(tpy)(OCMe)(OCR')] [R' = -Bu (), CF (), Ph ()], (-6-34)-[Pt(tpy)(OCCF)(OCR')] [R' = -Bu (), Me (), Ph ()], and (-6-34)-[Pt(tpy)(OC--Bu)(OCMe)] (). Irradiation of - and - with UV light (365 nm) in MeCN gives 5-methyl-2-(2-pyridyl)phenyl pivalate (), 5-methyl-2-(2-pyridyl)phenyl acetate () or 5-methyl-2-(2-pyridyl)phenyl benzoate () as the major photoproduct from most complexes, resulting from a reductive C-O coupling between a tpy ligand and a carboxylato ligand.
View Article and Find Full Text PDFSynthesis of Sulfenamides via Photoredox N-S Coupling of Dialkyl Azodicarboxylates and Thiols.
Org Lett
December 2024
College of Chemistry, Chemical Engineering and Materials Science, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Shandong Normal University, Jinan 250014, China.
We herein report a photoredox N-S coupling reaction between dialkyl azodicarboxylates and thiols to access sulfenamide scaffolds. This reaction proceeds under mild, green, and operationally simple conditions, offering a broad scope of sulfenamides with high yields and excellent atom efficiency. Mechanistic investigations revealed this reaction followed a photoinitiated radical pathway in which iodide plays a crucial role as both a radical initiator and a single-electron reductant.
View Article and Find Full Text PDFInfluence of calcium carbonate on ferrihydrite bio-transformation and associated arsenic mobilization/redistribution.
Environ Pollut
December 2024
State Environmental Protection Key Laboratory of Integrated Surface Water-Groundwater Pollution Control, School of Environmental Science and Engineering, Southern University of Science and Technology, Shenzhen 518055, China.
The sulfate-reducing bacteria (SRB)-induced ferrihydrite transformation is an important cause for arsenic (As) contamination in the aquifer near mining area. Calcium carbonate (CaCO) is widespread and has the potential of regulating As fate directly or indirectly. However, the influence of CaCO on ferrihydrite transformation and the associated As mobilization/redistribution in SRB-containing environments remains unclear.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!