Background: Asymptomatic and mild form of the neurocognitive disorder in individuals with human immunodeficiency virus infection is still prevalent and a chief problem worldwide although the severity of the neurocognitive complications is decreasing after the introduction of combined highly active antiretroviral therapy.
Aim: To study language and executive dysfunction of HIV patients in Clinical Stage 1 in an industrial scenario in Western Maharashtra as compared to healthy controls.
Material And Methods: The Wisconsin card sorting test and Addenbrooke cognitive scale were done to check for executive function and language, respectively, and compared to age- and gender-matched HIV-negative controls.
Results: Both the results of the WCST and Addenbrooke cognitive scale showed a decline in scores in the cases as compared to the controls overall. The distribution of cases as per the gender showed no significant difference, whereas there was a significant difference as per the age.
Conclusion: In asymptomatic HIV patients, there is a decline in executive function and language as compared to the healthy controls. As most of the individuals were employed, there is a need to assess their neurocognitive function regularly as the progress of the illness can be monitored and cognitive training can be advised in these HIV-positive patients, which will not only benefit the individuals but the industrial sector in the long run as well.
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http://dx.doi.org/10.4103/ipj.ipj_232_23 | DOI Listing |
Proc Natl Acad Sci U S A
January 2025
Center for Psychiatry Research and Center for Cognitive and Computational Neuropsychiatry, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm 17177, Sweden.
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View Article and Find Full Text PDFAnesthesiology
February 2025
Department of Anaesthesia and Pain Management, Royal Children's Hospital, Melbourne, Victoria, Australia; Murdoch Children's Research Institute, Parkville, Victoria, Australia; Department of Paediatrics, University of Melbourne, Melbourne, Victoria, Australia.
Background: The general anaesthesia or awake-regional anaesthesia in infancy (GAS) trial demonstrated evidence that most neurodevelopmental outcomes at 2 and 5 yr of age in infants who received a single general anesthetic for elective inguinal herniorrhaphy were clinically equivalent when compared to infants who did not receive general anesthesia. More than 20% of the children in the trial had at least one subsequent anesthetic exposure after their initial surgery. Using the GAS database, this study aimed to address whether multiple (two or more) general anesthetic exposures compared to one or no general anesthetic exposure in early childhood were associated with worse neurodevelopmental outcomes at 5 yr.
View Article and Find Full Text PDFJ Nerv Ment Dis
December 2024
Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, Section of Psychiatry, University of Genoa, Genoa, Italy.
This review aimed at summarizing the literature evidence on clinical, cognitive, and neurobiological correlates of impaired timing abilities in schizophrenia (SCZ). Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, a systematic literature search was conducted in PubMed, EMBASE, and PsycInfo by looking at correlates between timing abilities and either symptom severity, cognition, and neurobiological data (imaging and electroencephalography) in individuals with SCZ, without restrictions on study design. A total of 45 articles were selected: associations were identified between impaired timing performance and positive, negative, and disorganization symptoms, as well as with executive functioning, working memory, and attention.
View Article and Find Full Text PDFBrain Behav Immun Health
February 2025
Healthy Brain Ageing Program, Brain and Mind Centre, School of Psychology, Faculty of Science, University of Sydney, NSW, 2050, Australia.
Inflammation is becoming increasingly recognised as a core feature of dementia with evidence indicating that its role may vary and adapt across different stages of the neurodegenerative process. This study aimed to investigate whether the associations of high-sensitivity C-reactive protein (hs-CRP) with neuropsychological performance (verbal memory, executive function, processing speed) and cerebral white matter hyperintensities (WMHs) differed between older adults with subjective cognitive decline (SCD; = 179) and mild cognitive impairment (MCI; = 286). Fasting serum hs-CRP concentrations were grouped into low (<1.
View Article and Find Full Text PDFJ Gerontol B Psychol Sci Soc Sci
January 2025
Department of Social and Behavioral Sciences, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Objectives: Prosociality, defined as positive other-regarding intentions and behaviors, is a modifiable factor demonstrated to be associated with better mental, physical, and cognitive health in older adults. Prior studies have largely focused on individual prosocial behaviors, especially volunteering. This study examines whether prosocial intentions are associated with maintaining cognitive health over time.
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