AI Article Synopsis
- This study investigates the efficacy of cathodal tDCS to the right cerebellum combined with semantic feature analysis (SFA) for rehabilitating chronic aphasia patients post-stroke.
- Participants will be divided into two groups: one receiving the active treatment and the other receiving sham stimulation, with evaluations taking place at various intervals post-treatment.
- The long-term goal is to establish the necessary data for a Phase III trial that could solidify cerebellar tDCS as a viable therapy option for chronic aphasia.
Article Abstract
In this randomized, double-blind, sham-controlled trial of Cerebellar Stimulation for Aphasia Rehabilitation (CeSAR), we will determine the effectiveness of cathodal tDCS (transcranial direct current stimulation) to the right cerebellum for the treatment of chronic aphasia (>6 months post stroke). We will test the hypothesis that cerebellar tDCS in combination with an evidenced-based anomia treatment (semantic feature analysis, SFA) will be associated with greater improvement in naming untrained pictures (as measured by the change in Philadelphia Picture Naming Test), 1-week post treatment, compared to sham plus SFA. We will also evaluate the effects of cerebellar tDCS on naming trained items as well as the effects on functional communication, content, efficiency, and word-retrieval of picture description, and quality of life. Finally, we will identify imaging and linguistic biomarkers to determine the characteristics of stroke patients that benefit from cerebellar tDCS and SFA treatment. We expect to enroll 60 participants over five years. Participants will receive 15, 25-minute sessions of cerebellar tDCS (3-5 sessions per week) or sham tDCS combined with 1 hour of SFA treatment. Participants will be evaluated prior to the start of treatment, one-week post-treatment, 1-, 3-, and 6-months post treatment on primary and secondary outcome variables. The long-term aim of this study is to provide the basis for a Phase III randomized controlled trial of cerebellar tDCS vs sham with concurrent language therapy for treatment of chronic aphasia. The trial is registered with ClinicalTrials.gov NCT05093673.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10871367 | PMC |
| http://dx.doi.org/10.1101/2024.02.05.24302365 | DOI Listing |
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