AI Article Synopsis
- Food addiction (FA) is common in people with obesity and may contribute to difficulties in losing weight or maintaining weight loss.
- A study involving 113 people with obesity found that low doses of semaglutide significantly reduced FA symptoms, with prevalence dropping from 57.5% to 4.2% after four months.
- Despite higher initial BMI and fat mass in those with FA, semaglutide resulted in similar weight loss outcomes for both groups, indicating its effectiveness for managing FA alongside weight loss.
Article Abstract
Introduction: Food addiction (FA) is highly prevalent among people with obesity (PwO) and may constitute a key factor in weight loss failure or weight regain. GLP-1 analogues have been shown to act on the mesolimbic system, which is related to hedonic overeating and substance abuse. We aimed to study the effects of low doses of semaglutide on FA symptomatology and to evaluate whether the presence of FA have a negative impact on weight loss despite treatment with semaglutide.
Methods: One hundred and thirteen PwO (45.5 ± 10.2 years) were evaluated anthropometrically baseline and after four months of treatment with semaglutide. PwO were evaluated for the presence of FA by completing The Spanish version of the Yale Food Addiction Scale 2.0 questionnaire (YFAS 2.0).
Results: Baseline BMI and fat mass (%) were greater among PwO with FA (35.8 ± 4.5 vs 33 ± 3.9 kg/mand 44.2 ± 6.5 vs 40.1 ± 7.9%; = .01). After four months of treatment with semaglutide, the prevalence of FA diminished from 57.5% to 4.2% ( < .001). The percentage of weight loss (6.9 ± 12.7 vs 5.3 ± 4.6%; = .4) and the proportion of fat mass loss (2 ± 9 vs 1.6 ± 3.1%; = .7) were comparable between PwO with and without FA. No differences regarding side effects and treatment discontinuations were seen between the two groups.
Conclusion: Semaglutide is an effective tool for the amelioration of FA symptomatology among PwO. Despite PwO with FA had greater basal BMI and fat mass, semaglutide showed similar results compared to PwO without FA in terms of weight and fat mass loss at short term.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1080/10550887.2024.2315365 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Development and Evaluation of the "Eating More Consciously" Module of a Lifestyle Intervention Program to Prevent Medication-Induced Weight Gain in Psychiatric Patients: A One-Arm Pilot Study.
Alpha Psychiatry
November 2024
Department of Psychiatry und Psychotherapy, LMU Klinikum, München, Germany.
Objective: Overweight and obesity are health issues that are increasing worldwide. Patients with severe mental illness are particularly vulnerable for various reasons, including the intake of weight gain-associated drugs. In this pilot study, we targeted eating behavior as a predictor for medication-induced weight gain and developed a module of a prevention program ("Eating More Consciously") to be evaluated by psychiatric inpatients.
View Article and Find Full Text PDFMeasurement Invariance on the Nine-Item Avoidant/Restrictive Food Intake Disorder Screen (NIAS) by Age and Reporter Status: Comparing ARFID Symptoms Among Self-Reporting Adults and Adolescents and Parent Reports of Children and Adolescents.
Int J Eat Disord
January 2025
Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Objective: Self-report measures of ARFID symptoms (e.g., Nine-Item Avoidant/Restrictive Food Intake Disorder Screen [NIAS]) are used to assess symptom differences between groups.
View Article and Find Full Text PDF#natural, #vegan, #healing: A Content Analysis of Health Content Among Instagram Posts Focused on Cannabis Edibles.
Subst Use Misuse
January 2025
Department of Health, Behavior and Society, Johns Hopkins Bloomberg School of Public Health, Hampton House, Baltimore, MD, USA.
Background: Despite limited scientific evidence, public perceptions of cannabis as health enhancing are significant. As food products, cannabis edibles (edibles), may also leverage food-related associations that convey health. Social media is a prominent and influential source of largely unregulated cannabis information and a potential place to correct misinformation.
View Article and Find Full Text PDFBrain acid sphingomyelinase controls addiction-related behaviours in a sex-specific way.
Neurobiol Dis
January 2025
Department of Psychiatry and Psychotherapy, University Clinic, Friedrich-Alexander-University of Erlangen-Nürnberg, Schwabachanlage 6, 91054 Erlangen, Germany; Institute of Psychopharmacology, Central Institute of Mental Health, University of Heidelberg, J 5, 68159 Heidelberg, Germany.
Addiction is a chronic and severe mental disorder with high gender- and sex-specificity. However, the pathogenesis of this disorder is not fully elucidated, and no targeted pharmacotherapy is available. A growing body of evidence points out the potential involvement of the ceramide system in the pathophysiology of addiction.
View Article and Find Full Text PDFAssessing the impact of messages about reduced nicotine cigar products among people who use little cigar and cigarillo: Insights from a discrete choice experiment.
Nicotine Tob Res
January 2025
Department of Health Promotion, Education and Behavior, Arnold School of Public Health, University of South Carolina, Columbia, South Carolina, USA.
Introduction: The U.S. Food and Drug Administration's (FDA) pursuit of a low nicotine standard for cigarettes raises concerns that a focus on cigarettes may encourage people to use other combusted tobacco products, undermining the policy's effectiveness.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!