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Personalized oncology in pheochromocytomas and paragangliomas: integrating genetic analysis with machine learning.
Med Oncol
October 2024
Department of Pharmaceutical Chemistry, College of Pharmacy, Northern Border University, 91911, Rafha, Saudi Arabia.
Pheochromocytomas and paragangliomas (PCCs/PGLs) are uncommon neuroendocrine tumors with a significant genetic tendency. Approximately 35-40% of these tumors are associated with genetic factors. The present study performed a thorough analysis using publicly accessible genetic and clinical data from the Cancer Genome Atlas (TCGA) to examine the involvement of six genes, namely GBP1, KIF13B, GPT, CSDE1, CEP164, and CLCA1, in the development of PCCs/PGLs.
View Article and Find Full Text PDFIdentification and validation of metastasis-related gene ZG16 in the prognosis and progression in colorectal cancer.
Front Oncol
July 2024
Department of General Surgery, Affiliated Kunshan Hospital of Jiangsu University, Kunshan, China.
Background: Metastasis remains the leading cause of mortality among colorectal cancer (CRC) patients. Identification of new metastasis-related genes are critical to improve colorectal cancer prognosis.
Methods: Data on mRNA expression in metastatic and primary CRC was obtained from the Gene Expression Omnibus (GEO) database, including GSE81986, GSE41568, GSE71222, GSE21510, and GSE14333.
CLCA1, a tumour suppressor in hepatocellular carcinoma.
Dig Liver Dis
October 2024
Department of Gastroenterology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China. Electronic address:
Identification and Validation of SLC9A2 as A Potential Tumor Suppressor in Colorectal Cancer: Integrating Bioinformatics Analysis with Experimental Confirmation.
Curr Med Sci
June 2024
Department of Gastrointestinal Surgery, Zhongnan Hospital of Wuhan University, Wuhan, 430071, China.
Objective: To uncover the mechanisms underlying the development of colorectal cancer (CRC), we applied bioinformatic analyses to identify key genes and experimentally validated their possible roles in CRC onset and progression.
Methods: We performed Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis on differentially expressed genes (DEGs), constructed a protein-protein interaction (PPI) network to find the top 10 hub genes, and analyzed their expression in colon adenocarcinoma (COAD) and rectum adenocarcinoma (READ). We also studied the correlation between these genes and immune cell infiltration and prognosis and validated the expression of SLC9A2 in CRC tissues and cell lines using qRT-PCR and Western blotting.
CLCA1 1 in cancer: A tumor suppressor or oncogene?
Dig Liver Dis
October 2024
Department of Gastroenterology, Zibo Central Hospital, Zibo 255000, PR China. Electronic address:
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