AI Article Synopsis

  • First-degree atrioventricular block (1-AVB) is characterized by a prolonged PR interval (over 200 milliseconds) and has been viewed as a harmless heart condition.
  • Recent studies suggest there may be a link between a longer PR interval and a higher risk for developing atrial fibrillation (AF).
  • A review of 18 studies indicates that longer PR intervals could be an independent risk factor for AF, but highlights the necessity for more research on how specific PR interval lengths relate to AF risk.

Article Abstract

First-degree atrioventricular block (1-AVB), characterized by a PR interval exceeding 200 milliseconds, has traditionally been perceived as a benign cardiac condition. Recently, this perception has been challenged by investigations that indicate a potential association between PR prolongation and an elevated risk of atrial fibrillation (AF). To consolidate these findings, we performed a comprehensive review to assess the available evidence indicating a relationship between these two conditions. We searched MEDLINE and EMBASE databases as well as manually searched references of retrieved articles. We selected 18 cohort studies/meta-analyses involving general and special populations. Consistent findings across expansive cohort studies reveal that incremental increases in the PR interval may serve as an independent risk factor for AF. However, our analyses underscore the need for further research into the association between 1-AVB, defined by a specified PR interval cutoff, and the risk of AF.

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Source
http://dx.doi.org/10.1016/j.cpcardiol.2024.102469DOI Listing

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