AI Article Synopsis
- - The study investigates the connection between brain natriuretic peptide (BNP) levels and stroke severity in patients with atrial fibrillation (AF), finding a stronger association than previously understood.
- - Participants were divided into high-BNP (≥200 pg/mL) and low-BNP (<200 pg/mL) groups, revealing that the high-BNP group had more severe strokes and major vessel occlusions compared to the low-BNP group.
- - Results suggest high BNP levels can be an independent predictor of severe stroke at admission, highlighting their significance even before treatment with oral anticoagulants begins.
Article Abstract
Background: Brain natriuretic peptides (BNP) are an important diagnostic and prognostic marker in patients with heart failure. However, the relationship between BNP levels and stroke severity in patients with atrial fibrillation (AF) remains unelucidated. In this study, we aimed to investigate the association between stroke severity at admission and BNP levels.
Methods: In this prospective observational study, we used data from 513 patients with AF and acute ischemic stroke treated with oral anticoagulants (OAC) registered in the Multicenter Prospective Analysis of Stroke Patients Taking Oral Anticoagulants study. The patients were divided into two groups: high-BNP (≥200 pg/mL) and low-BNP level (<200 pg/mL) groups. We compared the clinical characteristics between the two groups and determined the effect of BNP levels on stroke severity on admission.
Results: Among the 513 enrolled patients, 248 (females, n = 30; median age, 82 years) and 265 (females, n = 76; median age, 71 years) were assigned to the high- and low-BNP level groups, respectively. The high-BNP level group had a higher proportion of patients with severe stroke (National Institutes of Health Stroke Scale score, ≥10) on admission (49.2% vs. 32.8%, p = 0.002) and major vessel occlusion (57.5% vs. 39.2%, p < 0.0001) than that had by the low-BNP level group. Multivariate analysis showed that high BNP level was independently associated with severe stroke on admission (odds ratio 1.07, 95% confidence interval 1.00-1.15; p = 0.0478).
Conclusions: High BNP level compared with low BNP level was associated with severe stroke and major vessel occlusion, even before OAC treatment.
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| http://dx.doi.org/10.1016/j.jns.2024.122935 | DOI Listing |
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