Poly(UG) or 'pUG' dinucleotide repeats direct gene silencing in Caenorhabditis elegans by adopting an unusual quadruplex structure. Humans have thousands of pUG sequences and proteins that interact with them. The pUG fold reveals new aspects of gene regulation and RNA folding, highlighting how a simple sequence can encode a complex structure.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11069436 | PMC |
| http://dx.doi.org/10.1016/j.tibs.2024.01.009 | DOI Listing |
Publication Analysis
Top Keywords
gene silencing
8
left-handed rna
4
rna quadruplex
4
quadruplex directs
4
directs gene
4
silencing polyug
4
polyug 'pug'
4
'pug' dinucleotide
4
dinucleotide repeats
4
repeats direct
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!